Chitosan Loaded Mucoadhesive Microspheres of Gliclazide - Journal

2. Prostaglandin-E induced enteropooling model:
2
Table:2 Effect of aqueous extracts of Mimosa pudica leaves on mean volume of intestinal fluid (ml) and their %
protection in prostaglandin-E 2 induced diarrhoea in rats
Groups Treatment Dose Mean volume of intestinal % of
fluid (ml) � SEM inhibition
I. Vehicle 1 ml of 5% v/v ethanol and 1.567 ± 0.08819 —
control normal saline p.o.
II. PGE control PGE 100 � g/kg 3.367 ± 0.09189 —
2
2
III. Standard 5 mg/kg 1.690 ± 0.03890 *** 79.21%
IV. AEMP 200mg/kg 2.467 ± 0.1256* 40.01%
V. AEMP 400mg/kg 2.155 ± 0.07482** 52.65%
AEMP: Aqueous Extract of Mimosa pudica, The values are Mean SEM, n = 6, *p < 0.05, **p < 0.01 and *** p < 0.001 vs control
Fig. 2: Effect of aqueous extracts of Mimosa pudica leaves on mean volume of intestinal fluid in prostaglandin-E 2
induced enteropooling model
3. Gastro-intestinal motility Test:
Md. Saifuddin Khalid et al./ Antidiarrhoeal Activity of Aqueous Extract of Mimosa Pudica Leaves
A: Vehical Control
B: PGE Control
2
C: Standard (Loperamide 5 mg/kg p. o.)
D: Aqueous extract of Mimosa pudica leaves (200 mg/kg p. o.)
E: Aqueous extract of Mimosa pudica leaves (400 mg/kg p. o.)
Table: 3 Effect of aqueous extracts of Mimosa pudica leaves on mean movement of charcoal and their %
inhibition in gastro-intestinal motility test in rats
Group Treatment Dose Mean length Mean distance Mean% movement of % of
of intestine travelled by charcoal charcoal±SEM inhibition
±SEM (cm) meal±SEM (cm) (cm)
I. control --- 106±0.7303 82.33±1.764 75.69 ± 0.4357 ----
II. Standard 5 102.7±1.02*** 53.33±0.8819*** 50.79 ± 0.8274*** 50%
(Atropine Sulphate)
III. AEMP 200 105±0.8944* 74.17±1.400* 67.46 ± 0.1014* 32.07%
IV. AEMP 400 103.8±1.014* 63.50±0.7638** 65.13 ± 0.1841* 34.65%
AEMP: Aqueous Extract of Mimosa pudica, The values are Mean SEM, n = 6, *p < 0.05, **p < 0.01 and *** p < 0.001 vs control
Fig 3: Effect of aqueous extracts of Mimosa pudica leaves on mean % movement of charcoal meal in
gastro-intestinal motility test
A: Control
B: Standard (Atropine sulphate 5 mg/kg p. o.)
C: Aqueous extract of Mimosa pudica leaves (200 mg/kg p. o.)
D: Aqueous extract of Mimosa pudica leaves (400 mg/kg p. o.)
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RJPS, Jul - Sep, 2011/ Vol 1/ Issue 2