Chitosan Loaded Mucoadhesive Microspheres of Gliclazide - Journal

Prakash Rao B et al./ Formulation and Evaluation of Mucoadhesive Buccal Drug Delivery System of Metoprolol Tartrate by Using Central Composite Design
Table 8: FT-IR spectrum of MT alone and excipients
Interpretation IR absorption IR absorption band of metoprolol
band of Pure
Metoprolol Drug + Drug + HPC
Tartrate(cm -1 )
-1
Carbopol (cm )
-1
(cm )
-NH 2 ,-OH,aliphatic 3610.79 – 2360.95 3608.93 – 2359.89 3611.83 – 2356.13
and aromatic CH
Carboxylic acid salt 1573.97 1580.14 1580.57
Aromatic ring 1514.17 1515.14 1513.21
Isopropyl group 1179.51 1180.47 1174.69
Aliphatic ether, 1112.00 1112.00 1112.00 1,4
secondary alcohol
di-substituted Benzene 824.24 826.53 824.60
Table 9: Result of stability studies according to ICH guidelines
Parameter 0 Days 6 months
Physical apperence White White
Drug content 49.06 49.05
Bioadhesive strength 43.52 43.12
physical changes of the substance are recorded as a function
of temperature or time as substance is heated at a liner rate.
The DTA of the pure drug shows two endothermic peaks(Fig
0
11). The peak at 123.19 C indicates its melting point and the
0
other peak at 223.12 C may be the degredation peak. In the
DTA studies there was no shift in the melting peak. So, the
selected excipients for the formulation were found to be
compatible with the active ingredients and having no physical
interaction with the active pharmaceutical ingredient.
Stabality Studies
The optimized formula was evaluated for physical
appearance, drug content and bioadhesive strength for every
month. The values given were at end of the six months. It
was found that optimized formula was stable.
CONCLUSION
The CCD was used to find out the effect of independent
varibles on the dependable variables. The result of CCD
revealed that the carbopol 934P and HPC have significant
effect on the drug release at 8 hour, bioadhesive strength,
T50% and release exponent(n). The observed independent
variables were found to be very close to predicted values of
optimized formulation which demonstrates the feasibility of
the optimization procedure in successful development of
buccal tablets containing MT by using carbopol 934P and
HPC.
155
REFERENCES
1. Shojaei AH. Buccal mucosa as a route for systemic drug delivery: A
review. J Pharm Sci 1998;1:15-30.
2. Patel VM, Prajapati BG, Patel MM. Formulation, evaluation and
composition of bilayer and multilayered mucoadhesive buccal device
of Propranolol hydrochloride. AAPS Pharm Sci Tech 2006;8:1-15.
3. Giunchedi P, Juliano C, Gavini E. Formulation and In-vivo evaluation
of Chlorhexidine buccal tablets prepared using a drug loaded
chitosan microspheres. Eur J Pharm Biopharm 2002; 53: 233-9.
4. Perioli L, Ambrogi V, Giovagnoli S, Ricci M, Blasi P, Rossi C.
Mucoadhesive bilayered tablets for buccal sustained release
Flurbiprofen. AAPS Pharm Sci Tech 2007; 8:1-9.
5. Desai KGH, Pramod kumar TM. Preparation and evaluation of a novel
buccal adhesive system. AAPS Pharm Sci Tech 2004; 5:1-9.
6. Munasur AP, Pillay V, Chetty DJ, Govender T. Statistical optimization
of the mucoadhesivity and characterisation of multipolymeric
Propranolol matrices for buccal therapy. Int J Pharm 2006; 323:43-51.
7. Yong CS, Jung JH, Rhee JP, Kim CK, Choi HG. Physicochemical
characterization and evaluation of buccal adhesive tablets containing
Omeprazole. Drug Dev Ind Pharm 2001;27: 447-55.
8. Yan MO, Choi HG, Jung JK, Kim CK. Development of
thermoreversible Insulin liquide suppository with sodium salicylate.
Int J Pharm 1999; 189:137-45.
9. Yamsani VV, Gannu R, Kolli C, Rao ME, Yamsani MR. Development
and In-vitro evaluation of buccoadhesive Carvedilol tablets. Acta
Pharm 2007;57:185-97.
10. Khanna R, Agrawal SP, Ahuja A. Preparation and evaluation of
bioerodible buccal tablets containing Clotrimazole. Int J Pharm 1996;
138:67-73.
11. Owens TS, Dansereau RJ, Sakr A. Development and evaluation of
extended release bioadhesive Sodium fluoride tablets. Int J Pharm
2005;288:109-22.
12.
th
Tripathi KD. Essentials of medical pharmacology. 5 ed. New Delhi:
Jaypee publishers. 2003;12913. Singh B, Chakkal SK,
Ahuja N. Formulation and optimization of controlled release
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