Prevention Guide - Safe Handling of Hazardous Drugs - Irsst
Prevention Guide - Safe Handling of Hazardous Drugs - Irsst
Prevention Guide - Safe Handling of Hazardous Drugs - Irsst
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
11. PATIENT CARE<br />
Table 8. <strong>Hazardous</strong> <strong>Drugs</strong>: Duration <strong>of</strong> the Presence <strong>of</strong> Detectable Residues in the Excreta<br />
Drug<br />
Duration <strong>of</strong> the Presence <strong>of</strong> Detectable<br />
Residues in the Urine<br />
Duration <strong>of</strong> the Presence <strong>of</strong><br />
Detectable Residues in the<br />
Stools<br />
Bleomycin sulfate 72 hr; 50% excreted in the first 24 hr --<br />
Busulfan 12-24 hr --<br />
Capecitabine 24 hr --<br />
Carboplatin 24-48 hr; 60% in the first 24 hr --<br />
Carmustine 4 days --<br />
Cisplatin 7 days --<br />
Cyclophosphamide 72 hr 5 days after oral dose<br />
Cytarabine 24 hr --<br />
Dacarbazine 6 hr --<br />
Dactinomycin 5 days; 20% in the first 24 hr --<br />
Daunorubicin 48 hr 7 days<br />
Docetaxel 7 days 7 days; 80% in the first 48 hr<br />
Doxorubicin 6 days 7 days<br />
Epirubicin 7 days 5 days<br />
Etoposide 4 days 7 days<br />
Fludarabine 48 hr --<br />
Fluorouracil 48 hr --<br />
Gemcitabine 7 days --<br />
Hydroxyurea 12 hr --<br />
Ifosfamide 48 hr --<br />
Imatinib mesylate 7 days 7 days<br />
Irinotecan 48 hr --<br />
Lomustine 24 hr --<br />
Mechlorethamine<br />
48 hr --<br />
hydrochloride<br />
Melphalan 48 hr 7 days<br />
Mercaptopurine 48-72 hr; 50% in the first 24 hr --<br />
Methotrexate 72 hr; major problem during the first 8 hr 7 days<br />
Mitomycin 24 hr --<br />
Mitoxantrone<br />
6 days 7 days<br />
hydrochloride<br />
Paclitaxel 24 hr 5 days<br />
Pegaspargase Not detectable --<br />
Tamoxifen -- 2 weeks<br />
Teniposide 5 days 48 hr<br />
Thioguanine 24 hr --<br />
Thiotepa 24 hr --<br />
Vinblastine sulfate 4 days 7 days<br />
Vincristine sulfate 4 days 7 days<br />
Source: ONS – <strong>Safe</strong> handling <strong>of</strong> hazardous drugs, 2003, p. 28.<br />
PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS ASSTSAS 11-5