Prevention Guide - Safe Handling of Hazardous Drugs - Irsst

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APPENDIX 4 – HAZARDOUS SPILL MANAGEMENT 4.3 Spill Report Form (sample) Any spill of more than 5 mL should be reported by completing a Spill Report Form (see sample). The Chemical Spill Report Form provided as part of the institution’s emergency measures planning process (see 12.3.4.1) may also be used. DATE, TIME AND LOCATION Spill Report Date: Location: Time assistance requested (Housekeeping or dedicated team): CIRCUMSTANCES SURROUNDING THE SPILL Names of individuals in contact with the spill: Time of spill management: CHECK OFF THE RECOMMENDED STEPS (COMMENTS, IF NECESSARY) Spill area isolated to prevent accidental contamination by workers or patients: Spill kit availability: Spill clean-up: COMPLETION OF THE REPORT Submission to the Head of the Pharmacy Department or the Unit Head or his representative, confirming the end of the spill: Spill management end time: A4-4 ASSTSAS PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS
5. MEASUREMENT OF WORK SURFACE CONTAMINATION CAUSED BY ANTINEOPLASTIC AGENTS APPENDIX 5 - Measurement of Work Surface Contamination Caused by Antineoplastic Agents Services Provided by the INSPQ Toxicology Laboratory At the request of the Hazardous Drug Committee (which procured the necessary funding), the INSPQ Toxicology Laboratory has developed a method for estimating the work surface contamination in institutions caused by antineoplastic agents. The tests are performed in the INSPQ laboratory. However, the specimens are collected in the institutions (in the clinics and hospitals) by the on-site workers, using sampling kits provided by the INSPQ. 5.1 Products Tested Cyclophosphamide, ifosfamide and methotrexate, with LOQ* = 0.01 ng/cm² * LOQ = Limit of quantification 5.2 Cost $50 per specimen collected. We recommend 12 specimens per pharmacy. Samples may also be taken in the care areas or at other steps of the medication circuit, depending on the client’s objectives. 5.3 Method Summary The analytical method is based on the recent article by Larson. 4 A standard-sized cloth, soaked in a special organic solution (10% acetonitrile, 25% methanol, buffered at pH 6), is used to wipe the work surfaces. Each specimen covers 600 cm² (20 cm x 30 cm), i.e., approximately the size of a piece of 8 ½ x 11 in. paper. The cloths are placed in a plastic tube and sent to the INSPQ laboratory. In the laboratory, 10 mL of the same solution are added and the cloth is agitated to release the products. An aliquot of the resulting solution is then analyzed using HPLC-MS-MS (an advanced spectrometry technique) to measure the concentration of antineoplastic agents present. The results are expressed in nanograms** per cm² (ng/cm²). ** 1 nanogram = 0.000 000 001 g, i.e., one billionth of a gram 4 RR Larson, MB Khazaeli, HK Dillon. “Monitoring method for surface contamination caused by selected antineoplastic agents”, Am. J. Health-Syst Pharm , 2002; 59(3): 270-7. PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS ASSTSAS A5-1
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Prevention Guide Safe Handling of H
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Prevention Guide Safe Handling of H
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This guide has been developed by th
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Table of Contents PREAMBLE ........
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List of Tables Table 1 Medication C
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PREAMBLE In September 2004, the Uni
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1. INTRODUCTION 1.1.1 Survey Regard
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1. INTRODUCTION 1.3 Guide Structure
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2. RISKS RELATED TO THE USE OF HAZA
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Pharmacy Care Wastes Support Receiv
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3. PREVENTION OBJECTIVES AND ACTION
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4. GENERAL PREVENTIVE MEASURES 4 GE
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4. GENERAL PREVENTIVE MEASURES 4.1.
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4. GENERAL PREVENTIVE MEASURES 4.1.
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4. GENERAL PREVENTIVE MEASURES clea
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4. GENERAL PREVENTIVE MEASURES Tabl
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4. GENERAL PREVENTIVE MEASURES Gras
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5. RECEIVING AND TRANSPORT 5.3.2 De
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6. UNPACKING AND STORAGE 6 UNPACKIN
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6. UNPACKING AND STORAGE 6.3.3 Unpa
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6. UNPACKING AND STORAGE 6.3.6 Spil
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7. PLANNING THE ONCOLOGY PHARMACY 7
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7. PLANNING THE ONCOLOGY PHARMACY
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7. PLANNING THE ONCOLOGY PHARMACY b
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Fridge 7. PLANNING THE ONCOLOGY PHA
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7. PLANNING THE ONCOLOGY PHARMACY T
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8. DRUG PREPARATION The product nev
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8. DRUG PREPARATION ‣ avoid sudde
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8. DRUG PREPARATION or “Caution
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8. DRUG PREPARATION 8.3.9 Preparing
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8. DRUG PREPARATION Wearing both
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9. TRANSPORT AND STORAGE FOLLOWING
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10. ADMINISTRATION OF DRUGS Adminis
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10. ADMINISTRATION OF DRUGS Nurses
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10. ADMINISTRATION OF DRUGS Primary
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10. ADMINISTRATION OF DRUGS Establi
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10. ADMINISTRATION OF DRUGS if a o
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10. ADMINISTRATION OF DRUGS 10.3.10
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10. ADMINISTRATION OF DRUGS 10.3.13
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10. ADMINISTRATION OF DRUGS contain
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11. PATIENT CARE 11 PATIENT CARE 11
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Page 123 and 124: 16. REFERENCES 16 REFERENCES AHQ [1
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