Prevention Guide - Safe Handling of Hazardous Drugs - Irsst

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APPENDIX 1 - GLOSSARY TERMS DEFINITIONS COMMENTS HEPA Filter HIIC or hyperthermic Intraoperative Intraperitoneal Chemotherapy Intrathecal High-efficiency filter to remove particulate from the air. ASHP HIIC is an innovative technique for the local control of the dissemination of cancer cells in the abdominal cavity. It consists of lavage of the abdominal cavity with a highly concentrated chemotherapeutic agent (concentration twenty times higher than that administered intravenously), heated to 43°C to increase the toxic effect of the chemotherapy on the cancer cells. This lavage can be performed with an open or closed abdomen during the surgical procedure and extended following the procedure in the intensive care phase. Administration via injection into the fluid contained between the thin layers of tissue covering the brain and spinal cord. National Cancer Institute (U.S.A.) ISO 5, 7, or 8 International Standard American Standard Level particles/m 3 particles/ft 3 ISO 5 3520 100 ISO 7 352 000 10 000 ISO 8 3 520 000 100 000 99.97% effective in filtering out particulate 0.3 microns in diameter. The clean rooms are classified according to the number of particles per unit of volume. The conventional standard, US FED STD 209E, used cubic feet, but has been replaced by ISO Standard 14644-l, expressed in cubic metres. Lab Coat Material Safety Data Sheet (MSDS) Mutagenic Packaging Material Personal Protective Equipment (PPE) ISO Standard 14644-1 Disposable or reusable, long-sleeved garment, buttoned in the back or front, worn over other clothing to avoid soiling it. ASHP Summary of the toxicological, physical and chemical properties of a chemical agent and the preventive measures required to handle it safely. This sheet is provided by the manufacturer. ASHP Substance capable of producing genetic modifications in living organisms. ASHP Packaging items in direct contact with the sterile product. OPQ Equipment that protects the worker from exposure to physical or chemical risks. ASHP Usually made of permeable material. E.g. gloves, gowns, respirators, goggles or protective face shields, etc. A1-4 ASSTSAS PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS
APPENDIX 1 - GLOSSARY TERMS DEFINITIONS COMMENTS Pharmaceutical Waste Raw Material Respiratory Protection Apparatus (RPA) Respirator Sterile Sterile Preparation Cabinets Surface Decontamination USP 797 Vesicant Pharmaceuticals (drugs or medicinal chemical agents) which are no longer usable for care or which are expired or contaminated, have not been properly stored or are no longer required. CSA ♦ CSHP Any substance of defined quality, with the exception of packaging materials, used for the preparation of sterile products. OPQ Type of personal protective equipment that prevents hazardous products from reaching the respiratory system, usually via a filtration process or the flow of uncontaminated air. ASHP Free of micro-organisms capable of multiplying. OPQ See Biological Safety Cabinets. Transfer of a hazardous drug contaminant from a fixed surface (counter, solution bag, etc.) to a disposable surface (towels, cloths, etc.). ASHP American standard for the preparation of sterile products. Issued in January 2004. Any agent that may lead to blister formation, severe tissue injury or tissue necrosis in the presence of extravasation. Mosby’s Medical, Nursing and Allied Health Dictionary If they have been contaminated by cytotoxic agents, they must be considered cytotoxic pharmaceutical waste. Example: RPA N95 or N100 A surgical mask does not provide the worker with respiratory protection. It is not an approved RPA. There is no established procedure for the decontamination of surfaces contaminated by hazardous drugs. Use of a gauze pad soaked in alcohol, sterile water, peroxide or sodium hypochlorite may be effective. There are no products universally effective against every hazardous drug. Under review in 2006. PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS ASSTSAS A1-5
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Prevention Guide Safe Handling of H
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Prevention Guide Safe Handling of H
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This guide has been developed by th
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Table of Contents PREAMBLE ........
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List of Tables Table 1 Medication C
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PREAMBLE In September 2004, the Uni
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1. INTRODUCTION 1.1.1 Survey Regard
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1. INTRODUCTION 1.3 Guide Structure
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2. RISKS RELATED TO THE USE OF HAZA
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Pharmacy Care Wastes Support Receiv
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3. PREVENTION OBJECTIVES AND ACTION
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4. GENERAL PREVENTIVE MEASURES 4 GE
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4. GENERAL PREVENTIVE MEASURES 4.1.
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4. GENERAL PREVENTIVE MEASURES 4.1.
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4. GENERAL PREVENTIVE MEASURES clea
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4. GENERAL PREVENTIVE MEASURES Tabl
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4. GENERAL PREVENTIVE MEASURES Gras
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5. RECEIVING AND TRANSPORT 5.3.2 De
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6. UNPACKING AND STORAGE 6 UNPACKIN
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6. UNPACKING AND STORAGE 6.3.3 Unpa
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6. UNPACKING AND STORAGE 6.3.6 Spil
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7. PLANNING THE ONCOLOGY PHARMACY 7
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7. PLANNING THE ONCOLOGY PHARMACY
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7. PLANNING THE ONCOLOGY PHARMACY b
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Fridge 7. PLANNING THE ONCOLOGY PHA
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7. PLANNING THE ONCOLOGY PHARMACY T
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8. DRUG PREPARATION The product nev
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8. DRUG PREPARATION ‣ avoid sudde
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8. DRUG PREPARATION or “Caution
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8. DRUG PREPARATION 8.3.9 Preparing
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8. DRUG PREPARATION Wearing both
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9. TRANSPORT AND STORAGE FOLLOWING
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Page 99 and 100: 11. PATIENT CARE 11 PATIENT CARE 11
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Page 106 and 107: 12. MANAGEMENT OF WASTE, ACCIDENTAL
Page 112 and 113: 13. HYGIENE AND SANITATION 13.2 Exp
Page 115: 14. LAUNDRY 14 LAUNDRY 14.1 Issues
Page 118 and 119: 15. MEDICAL, BIOLOGICAL AND ENVIRON
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Page 123 and 124: 16. REFERENCES 16 REFERENCES AHQ [1
Page 125: 16. REFERENCES Nygren O., Lundgren
Page 129 and 130: APPENDIX 1 - GLOSSARY APPENDIX 1- G
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Page 136 and 137: APPENDIX 2 - LIST OF HAZARDOUS DRUG
Page 142 and 143: APPENDIX 3 - SURVEY REGARDING PRACT
Page 149 and 150: APPENDIX 4 - HAZARDOUS SPILL MANAGE
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Page 153 and 154: 5. MEASUREMENT OF WORK SURFACE CONT
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