Prevention Guide - Safe Handling of Hazardous Drugs - Irsst
Prevention Guide - Safe Handling of Hazardous Drugs - Irsst
Prevention Guide - Safe Handling of Hazardous Drugs - Irsst
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10. ADMINISTRATION OF DRUGS<br />
10.3.13 Administration via Aerosolization RATING: ++<br />
Use an administration technique that limits the risk <strong>of</strong> exposure to pentamidine and<br />
ribavirin.<br />
RECOMMENDATIONS<br />
NOTE<br />
Pentamidine and Ribavirin<br />
The risk is lower if the patient is intubated and ventilated. In this case, some <strong>of</strong> the<br />
containment measures described below do not apply (10.3.13.1, 10.3.13.2, 10.3.13.3) or<br />
apply only in part, (depending on the situation) (10.3.13.4, 10.3.13.5).<br />
10.3.13.1 These drugs should be administered in a cubicle or tent specifically provided for this<br />
purpose in a negative-pressure chamber with at least 6 air changes per hour. There are<br />
various tent and cubicle systems on the market, for example, Demistifier (Figure 22). If<br />
this equipment is not available, the room should have 12 changes <strong>of</strong> air per hour. Do not<br />
administer these drugs in a positive-pressure room. Keep the door to the room closed at all<br />
times to ensure that the negative pressure is maintained. The room should continue to be<br />
ventilated for 30 minutes after the end <strong>of</strong> the treatment.<br />
FIGURE 22<br />
Various containment options for the administration <strong>of</strong> pentamidine or ribavirin<br />
10.3.13.2 The air from the cubicle, tent or room should be exhausted to the outdoors; otherwise, it<br />
should be filtered through a HEPA filter.<br />
10-14 ASSTSAS PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS