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Prevention Guide - Safe Handling of Hazardous Drugs - Irsst

Prevention Guide - Safe Handling of Hazardous Drugs - Irsst

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10. ADMINISTRATION OF DRUGS<br />

10.3.13 Administration via Aerosolization RATING: ++<br />

Use an administration technique that limits the risk <strong>of</strong> exposure to pentamidine and<br />

ribavirin.<br />

RECOMMENDATIONS<br />

NOTE<br />

Pentamidine and Ribavirin<br />

The risk is lower if the patient is intubated and ventilated. In this case, some <strong>of</strong> the<br />

containment measures described below do not apply (10.3.13.1, 10.3.13.2, 10.3.13.3) or<br />

apply only in part, (depending on the situation) (10.3.13.4, 10.3.13.5).<br />

10.3.13.1 These drugs should be administered in a cubicle or tent specifically provided for this<br />

purpose in a negative-pressure chamber with at least 6 air changes per hour. There are<br />

various tent and cubicle systems on the market, for example, Demistifier (Figure 22). If<br />

this equipment is not available, the room should have 12 changes <strong>of</strong> air per hour. Do not<br />

administer these drugs in a positive-pressure room. Keep the door to the room closed at all<br />

times to ensure that the negative pressure is maintained. The room should continue to be<br />

ventilated for 30 minutes after the end <strong>of</strong> the treatment.<br />

FIGURE 22<br />

Various containment options for the administration <strong>of</strong> pentamidine or ribavirin<br />

10.3.13.2 The air from the cubicle, tent or room should be exhausted to the outdoors; otherwise, it<br />

should be filtered through a HEPA filter.<br />

10-14 ASSTSAS PREVENTION GUIDE – SAFE HANDLING OF HAZARDOUS DRUGS

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