discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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Conceptual Models<br />
PK<br />
e a ( −ket) ( −kat)<br />
Cp<br />
= e − e + ei<br />
Cl( ka<br />
−ke)<br />
⎣<br />
⎦<br />
PD<br />
Dk k<br />
⎡<br />
⎤<br />
% of Movility<br />
85,00<br />
84,50<br />
84,00<br />
83,50<br />
83,00<br />
82,50<br />
82,00<br />
81,50<br />
81,00<br />
80,50<br />
80,00<br />
79,50<br />
79,00<br />
78,50<br />
78,00<br />
Y i = X i b + Z i b i + e i<br />
2 4 6 8 10 12 14<br />
Weeks c s n<br />
Repeated measures models<br />
Phase II-IV<br />
EF<br />
( E<br />
e<br />
max<br />
=<br />
Log ( EC )<br />
+ b1<br />
i)<br />
dosis<br />
50<br />
+ dosis<br />
PK/PD<br />
10
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