discrete-event simulation in clinical trials - Institut für Statistik ...

Mixed model: General form
‣ Linear mixed model form:
Y
i
= X β + Z b + ε
‣ Y i vector of observations
‣ X i y Z i design matrix
‣ β fixed parameters vector
‣ b i ~ N(0,D) random vector of
observations
‣ ε i ~ N(0,Σ i ) residual vector
‣ b i y ε i they are independent
i
i
i
i
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