discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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Determ<strong>in</strong>ation of the end<strong>in</strong>g moment of the CT:<br />
The ed<strong>in</strong>g moment CT have calculated (Day 0 a Visit 10 month) per<br />
hospital, us<strong>in</strong>g 40 <strong>simulation</strong> replications:<br />
•Hospital 1: 385,525 [381,132; 389,917] days<br />
•Hospital 2: 385,975 [381,169; 390,780] days<br />
•Hospital 3: 393,575 [388,773; 398,376] days<br />
8<br />
7<br />
6<br />
5<br />
4<br />
3<br />
2<br />
1<br />
0<br />
Centro 1<br />
Centro 2<br />
Centro 3<br />
234<br />
264<br />
275<br />
280<br />
287<br />
292<br />
297<br />
302<br />
308<br />
315<br />
321<br />
326<br />
331<br />
336<br />
343<br />
350<br />
363<br />
374<br />
399<br />
Duration od the Cl<strong>in</strong>ical trial(days)<br />
Duración del ensayo clínico (días)<br />
Simulation scenarios:<br />
1- Increase 50 % the speed of recruitment respect regard to the <strong>in</strong>itial<br />
model:<br />
•Hospital 1: 381,125 [375,822; 386,427] días<br />
•Hospital 2: 387,475 [381,271; 317,222] días<br />
•Hospital 3: 391,075 [386,617; 395,532] días<br />
2-The recruitment period for the 3 hopitals has been changed for 90<br />
days average:<br />
•Hospital 1: 531,414 [519,611; 543,217] días<br />
•Hospital 2: 532,829 [522,036; 543,622] días<br />
•Hospital 3: 535,780 [525,433; 546,127] días<br />
33
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