discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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‣Validation/Verification methodologies for<br />
complex <strong>simulation</strong> models<br />
C oncentración (m g/L)<br />
12<br />
10<br />
8<br />
6<br />
4<br />
2<br />
0<br />
0 2 4 6 8 10 12 14 16 18 20 22 24<br />
Tiempo (h)<br />
Conceptual<br />
Conceptual model<br />
Concentración Real data real<br />
Concentración (mg/L)<br />
12<br />
10<br />
8<br />
6<br />
4<br />
2<br />
Simulation model (IC95%)<br />
0<br />
0 2 4 6 8 10 12 14 16 18 20 22 24<br />
Tiempo (h)<br />
Simulation<br />
Simulación Conceptual<br />
PVLIR<br />
i<br />
LLR − LLRi<br />
100<br />
LLR<br />
=<br />
2<br />
2<br />
35
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