discrete-event simulation in clinical trials - Institut für Statistik ...

Modelization/Simulation process
Statistical analysis (p-value,…)
PK models
2 compartent 1st order model, macro-constants, lagtime,
1st order elimination
( − α t ) + b exp ( − t ) + c exp ( k t )
C ( t)
= a exp
β −
01
discrete approximation of the continuous differential equations
n replications
Statistical analysis -
inference (p-value,…)
Monte-Carlo
Simulation
y = f ( t , b ) + e
b
i i i i
= X B +
ZB
i i i i
13