discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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Dk<br />
k<br />
[ exp( −ket)<br />
− exp( −kat<br />
] ei<br />
e a<br />
C<br />
p<br />
= ) +<br />
Cl(<br />
ka<br />
− ke<br />
)<br />
where<br />
k<br />
a<br />
= exp(0,47 + b )<br />
0i<br />
Cl = exp( − 3,22 + b )<br />
b0i∼N(0; 0,03),<br />
b1i∼N(0;0,4)<br />
eij∼N(0; 0,7).<br />
1i<br />
9