discrete-event simulation in clinical trials - Institut für Statistik ...

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The solution of the DE system model will be discretized and its parametes estimated by means of NLMM to contemplate population variations with<strong>in</strong> and betwen subjetcs. 8
Dk k [ exp( −ket) − exp( −kat ] ei e a C p = ) + Cl( ka − ke ) where k a = exp(0,47 + b ) 0i Cl = exp( − 3,22 + b ) b0i∼N(0; 0,03), b1i∼N(0;0,4) eij∼N(0; 0,7). 1i 9
Page 1 and 2: DRUGS CLINICAL TRIAL OPTIMIZATION U
Page 3 and 4: Schedule • Clinical trial framewo
Page 5 and 6: Randomization 5
Page 7: The bio-pharmacological basis of cl
Page 11 and 12: Simulation general framework
Page 13 and 14: Modelization/Simulation process Sta
Page 15 and 16: Sargent paradigm 15
Page 17 and 18: Statistic phases of the process ‣
Page 19 and 20: Operational validation: methodologi
Page 21 and 22: Mixed model: General form ‣ Linea
Page 23 and 24: Types of simulations in function of
Page 25 and 26: SIMULATION METHODOLOGY: Statistical
Page 27 and 28: Realistic simulation by means of di
Page 29 and 30: STATISTICAL MODELLING 1-Disease pro
Page 31 and 32: N=144 Start of CT W(10) 0 months Ti
Page 33 and 34: Determination of the ending moment
Page 35 and 36: ‣Validation/Verification methodol
Page 37: Vielen dank für Ihre Aufmerksamkei

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