discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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The bio-pharmacological basis of cl<strong>in</strong>ical <strong>trials</strong><br />
Drug <strong>in</strong> pharmaceutical form<br />
Compartment models<br />
Particle<br />
Periferic compartment (tissues)<br />
Liver<br />
Central compartment<br />
Biological effects<br />
Disolution<br />
dose ⎛ CL ⎞<br />
C ( t)<br />
= exp ⎜ − t ⎟<br />
V ⎝ V ⎠<br />
( t)<br />
= a exp − α t + b exp − β t + c exp − k<br />
( ) ( ) ( t )<br />
C<br />
01<br />
7
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