discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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Operational validation:<br />
methodological difficulties<br />
‣ Given an<br />
end po<strong>in</strong>t, a<br />
perfectly<br />
valid model<br />
will be<br />
rejected if<br />
the patient<br />
size (of<br />
<strong>simulation</strong>)<br />
is<br />
sufficiently<br />
big<br />
19
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