discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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CONCEPTUAL MODEL SIMULATION (Plann<strong>in</strong>g)<br />
Generator<br />
N=144<br />
W(β=2, δ, γ=0)<br />
W 1<br />
W<br />
δ =10<br />
2 W 3<br />
δ =15 δ =20<br />
HOSPITAL 1<br />
HOSPITAL 2<br />
HOSPITAL 3<br />
n=6 visits<br />
W i<br />
+ t j<br />
+ N(0, 10) [t = time between visits]<br />
Wait<strong>in</strong>g<br />
Server<br />
p withdrawn<br />
=0,03<br />
.<br />
.<br />
.<br />
10,3<br />
.<br />
.<br />
.<br />
Change <strong>in</strong> attributes<br />
Pacebo (Conceptual)<br />
Destructor:<br />
End<br />
Destructor:<br />
Withdrawn<br />
Y (unidades)<br />
10,25<br />
10,2<br />
10,15<br />
Modelo de enfermedad<br />
Placebo<br />
10,1<br />
0 2 4 6 8 10<br />
Tiempo (meses)<br />
Treatment<br />
assignation<br />
50 mg<br />
100 mg<br />
Y (unidades)<br />
16<br />
15<br />
14<br />
13<br />
12<br />
11<br />
Pacebo (Conceptual)<br />
50 mg (Conceptual) Dosis de máximo efecto<br />
100 mg (Conceptual)<br />
Dosis óptima<br />
Modelo de enfermedad<br />
10<br />
0 2 4 6 8 10<br />
Tiempo (meses)<br />
Riesgo AA<br />
1,2<br />
1<br />
0,8<br />
0,6<br />
0,4<br />
Placebo (Conceptual)<br />
50 mg (Conceptual)<br />
100 mg (Conceptual)<br />
0,2<br />
0<br />
0 5 10 15 20 25<br />
Tiempo (meses)<br />
30
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