discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
discrete-event simulation in clinical trials - Institut für Statistik ...
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Use of mixed models <strong>in</strong> CTS<br />
‣ Statistical model used<br />
frequently to conceptual<br />
hierarchical (multilevel) of<br />
repeated measures and <strong>in</strong><br />
PK/PD (Proc MIXED /<br />
NLMIXED <strong>in</strong> SAS).<br />
‣ We can model covariance<br />
structure “between” levels and<br />
“with<strong>in</strong>” levels.<br />
‣ We can calculate <strong>in</strong>dividual<br />
trajetories for any patient<br />
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