chemia - Studia

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EVALUATION OF THE ANTIOXIDANT CAPACITY OF A SERIES OF ACYL-HYDRAZONES BEARING … Figure 1. Influence of the compounds on the total oxidant status (TOS) Figure 2. Influence of the compounds on the total antioxidant response (TAR) Compounds 8 and 13 reduced TOS more powerful (p
CRISTINA MARIANA MOLDOVAN, ALINA PÂRVU, BRÎNDUŞA TIPERCIUC, OVIDIU ONIGA Figure 3. Variation of the index of oxidative stress (OSI) for the tested compounds Analyzing the structural profile of the tested acyl-hydrazones, it could be observed that N’-(4-(2-(2-phenyl-4-methyl-thiazole-5-yl)-2-oxoethoxi)-benzylidenaryl-hydrazides 1 and 2 presented a prooxidant activity. The substitution in para of the benzylidene fragment from position 2 of thiazole with brome resulted in the reduction of the antioxidant potential of the N’-(2), (3), 4-((2-phenyl-thiazole- 4-yl)-methoxi)-benzyliden-hidrazides 3-14, compared with the unsubstituted compounds. Two compounds of this series, 8 and 13, demonstrated a more potent antioxidant capacity than meloxicam, the reference drug. For these two derivatives, a significant decrease of OSI was registered. CONCLUSIONS The study on the effect of acyl-hydrazones on the oxidative stress indicated antioxidant properties for compounds 4-6, 10, 12. These derivatives determined a significant reduction of the total oxidant status and an increase of the total antioxidant response. For compounds 8 and 13, the decrease of the index of oxidative stress resulted from the more pronounced reduction of TOS and more pronounced increase of TAR, in the case of compound 7. On the other hand, acyl-hydrazones 1 and 2 developed a prooxidant effect. SAR study showed that the substitution of phenyl from position 2 of thiazole with brome, in position 4, led to a reduction of the antioxidant capacity. EXPERIMENTAL SECTION The experiments were performed on adult male Wistar-Bratislava albino rats, weighing 200–250g. The animals were obtained from the Biobase of University of Medicine and Pharmacy Cluj-Napoca and housed at 25 ± 2 C o , 32
Page 1 and 2: CHEMIA 4/2010
Page 3 and 4: L.M. PĂCUREANU, A. BORA, L. CRIŞA
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MODELING THE BIOLOGICAL ACTIVITY OF
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LILIANA M. PĂCUREANU, ALINA BORA,
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A. R. ASHRAFI, P. NIKZAD, A. BEHMAR
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GHOLAM HOSSEIN FATH-TABAR, ALI REZA
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GHOLAM HOSSEIN FATH-TABAR, ALI REZA
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MODJTABA GHORBANI symmetric but it
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MODJTABA GHORBANI group can be comp
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MODJTABA GHORBANI 10. P.V. Khadikar
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HOSSEIN SHABANI, ALI REZA ASHRAFI,
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MIRCEA V. DIUDEA, CSABA L. NAGY, PE
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STUDIA UBB. CHEMIA, LV, 4, 2010 WIE
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WIENER INDEX OF MICELLE-LIKE CHIRAL
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WIENER INDEX OF MICELLE-LIKE CHIRAL
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STUDIA UBB. CHEMIA, LV, 4, 2010 TUT
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TUTTE POLYNOMIAL OF AN INFINITE CLA
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TUTTE POLYNOMIAL OF AN INFINITE CLA
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ALI REZA ASHRAFI, HOSSEIN SHABANI,
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MOHAMMAD A. IRANMANESH, A. ADAMZADE
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MOHAMMAD A. IRANMANESH, A. ADAMZADE
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RALUCA O. POP, MIHAI MEDELEANU, MIR
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MELINDA E. FÜSTÖS, ERIKA TASNÁDI
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STUDIA UBB. CHEMIA, LV, 4, 2010 APP
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APPLICATION OF NUMERICAL METHODS IN
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APPLICATION OF NUMERICAL METHODS IN
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VLADIMIR R. ROSENFELD, DOUGLAS J. K
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MAHSA GHAZI, MODJTABA GHORBANI, KAT
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MAHSA GHAZI, MODJTABA GHORBANI, KAT
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M. GHORBANI, M. A. HOSSEINZADEH, M.
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MONICA STEFU, VIRGINIA BUCILA, M. V
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MONICA STEFU, VIRGINIA BUCILA, M. V
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MAHBOUBEH SAHELI, RALUCA O. POP, MO
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MAHBOUBEH SAHELI, RALUCA O. POP, MO
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FARZANEH GHOLAMI-NEZHAAD, MIRCEA V.
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MAHBOUBEH SAHELI, MIRCEA V. DIUDEA
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MAHBOUBEH SAHELI, ALI REZA ASHRAFI,
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STUDIA UBB. CHEMIA, LV, 4, 2010 OME
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OMEGA POLYNOMIAL IN CRYSTAL-LIKE NE
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OMEGA POLYNOMIAL IN CRYSTAL-LIKE NE
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STUDIA UBB. CHEMIA, LV, 4, 2010 CLU
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CLUJ CJ POLYNOMIAL AND INDICES IN A
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ALI REZA ASHRAFI, ASEFEH KARBASIOUN
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POPA IULIANA, DRAGOŞ ANA, VLĂTĂN
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ALI IRANMANESH, YASER ALIZADEH, SAM
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DIÁNA WEISER, ANNA TOMIN, LÁSZLÓ
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P. FALUS, Z. BOROS, G. HORNYÁNSZKY
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L. VLASE, M. PÂRVU, A. TOIU, E. A.
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MIRCEA V. DIUDEA ⎧max l( pi, j),
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MIRCEA V. DIUDEA Pi () k = [ LM, Sh
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MIRCEA V. DIUDEA CONCLUSIONS The re
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