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Train the Trainer Course book - Cochrane Public Health Group

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Systematic review – critical appraisal exercise<br />

DiCenso A, Guyatt G, Griffith WL. Interventions to reduce unintended pregnancies among<br />

adolescents: systematic review of randomised controlled trials. BMJ 2002;324:1426-34.<br />

Screening questions<br />

1. Did <strong>the</strong> review address a clearly focused<br />

research question?<br />

HINT:A research question can be 'focused' in<br />

terms of<br />

- <strong>the</strong> population studied<br />

- <strong>the</strong> intervention given<br />

- <strong>the</strong> outcomes considered<br />

Yes.<br />

Population – children 11-18 years<br />

Intervention – Primary pregnancy prevention<br />

programmes – sex education classes, school<br />

based clinics, family planning clinics,<br />

community based programmes.<br />

Control: NOTE: Comparison is conventional sex<br />

education, comparison is not no intervention.<br />

This review is only measuring <strong>the</strong> difference<br />

between <strong>the</strong> two, and is in fact comparing<br />

<strong>the</strong>ory-led approaches to conventional<br />

approaches. It is not answering <strong>the</strong> question of<br />

sex education versus no education.<br />

2. Did <strong>the</strong> review include <strong>the</strong> right type of<br />

studies?<br />

HINT: These would<br />

- address <strong>the</strong> review's research question<br />

- have an appropriate study design<br />

Detailed questions<br />

3. Did <strong>the</strong> reviewers try to identify all<br />

relevant studies?<br />

HINT:Look for<br />

- which bibliographic databases were used<br />

- follow up from reference lists<br />

- personal contact with experts<br />

- search for unpublished as well as published<br />

studies<br />

Outcomes – delay in sexual intercourse,<br />

consistent use of birth control, avoidance of<br />

unintended pregnancy<br />

Probably not<br />

Although <strong>the</strong> effectiveness of interventions is<br />

best measured using RCTs, this review could<br />

have benefited from including high quality nonrandomised<br />

controlled trials. This type of<br />

intervention would normally be measured using<br />

non-RCTs (in ‘real-life’) in most countries, and<br />

high quality non-RCTs in this review could<br />

contribute more than poorly-designed RCTs.<br />

Therefore, this review should have included<br />

both kinds of studies. The authors could have<br />

separated <strong>the</strong> results for non-RCTs and RCTs to<br />

see if <strong>the</strong> inclusion criteria made any difference<br />

to <strong>the</strong> final results.<br />

Yes.<br />

Searched databases from 1970 to December<br />

2000.<br />

Used:<br />

McMaster Teen Project database<br />

Electronic databases, conference papers<br />

Dissertation abstracts<br />

Reviewed content lists of journals<br />

139

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