Proceedings of the meeting - Department of Physics - University of ...
Proceedings of the meeting - Department of Physics - University of ...
Proceedings of the meeting - Department of Physics - University of ...
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Clinical Neurospectroscopy:In this field which is one <strong>of</strong> <strong>the</strong> most well known applications <strong>of</strong> MR Spectroscopywe tend to use Single or Multiple Voxel Studies <strong>of</strong> <strong>the</strong> brain using Probe ( ProtonBrain Examination ) and ProbeQ (which adds semiquantative data).Single Voxel Technique:• STEAM ( Stimulated echo acquisition mode)o A localization method which uses 3 water suppression pulses ( 90 – TE/2-90 –TM-90-TE/2-ECHO) – 3 RF pulses select box.o Results in Probe Spectrum <strong>of</strong> box.o Choice <strong>of</strong> traditional spectroscopists - using STEAM libraries.• PRESS ( Point Resolved Spectroscopy)o A double spin echo technique (90-TE1/2-180- TE1/2-TE2/2- 180 – TE2/2 –ECHO). 3 RF pulses select a voxelo Results in Probe Spectrum <strong>of</strong> voxelo PRESS has 2x SNR <strong>of</strong> STEAM!o Metabolite peaks look differentVariation with Age Down’s & Dementia Metabolic Disease
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