- Page 1 and 2: Silica Immobilised MetalIon Activat
- Page 3 and 4: ABSTRACTImmobilisation of functiona
- Page 5: DECLARATIONI certify that this thes
- Page 8 and 9: EtOHGPDMSGPDMESGPSGPTSethanolglycid
- Page 12 and 13: Figure 1.1X-ray determined crystal
- Page 14 and 15: documented throughout the literatur
- Page 16 and 17: enthalpy changes, resulting from co
- Page 18 and 19: forces and essentially the whole ga
- Page 20 and 21: environment to the hydrophobic inte
- Page 22 and 23: To preserve the cone conformation a
- Page 24 and 25: acetone-d 6 . For instance, the log
- Page 26 and 27: e appreciated that many biological
- Page 28 and 29: an aromatic ring centroid, F(2A) ..
- Page 30 and 31: 111, 121and chelation therapy.The e
- Page 32 and 33: co-workers in their investigations
- Page 34 and 35: first generation water soluble ioni
- Page 36 and 37: preconcentration of metal ions from
- Page 38 and 39: Si-GPS, 33Figure 1.13 Silica attach
- Page 40 and 41: 3637The loading of macrocycle obtai
- Page 42 and 43: In the host-guest complex 39, forme
- Page 44 and 45: anionic guest species in aqueous co
- Page 46 and 47: CHAPTER 2SYNTHESIS OF MACROCYCLIC R
- Page 48 and 49: groups and guest species are augmen
- Page 50 and 51: 21R 1 = protecting group 1R 2 = pro
- Page 52 and 53: is that the electron withdrawing ca
- Page 54 and 55: The chiral phenolic epoxide 56 was
- Page 56 and 57: phenolic oxygen of 66 or 67 over Pd
- Page 58 and 59: ROHHORROHHOROONNNNHOHO74,Pd/CEtOHNH
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The model receptor ligand 51 was pr
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hereafter referred to as [Cd(TracHP
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CHAPTER 3GUEST MOLECULE INCLUSION S
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comprehensive description of the me
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3.2.3 Job’s plots for host-guest
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studies undertaken with the first g
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6.886.68δobs (ppm)6.486.286.085.88
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Figure 3.9The structure of histidin
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Na +Figure 3.11 Generic structure d
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An example of the titration curves
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pK a = 2.97 pK a = 1.05Figure 3.15
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CHAPTER FOURMODIFICATION OF THE SIL
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GPTS,32(3-(glycidoxypropyl)trimetho
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(glycidoxypropyl)dimethylethoxysila
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TMCS is a small molecule that can g
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4.2 Characterisation of modified si
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for Si-GPS, 33. The symmetric v (Si
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ands for para substituted aromatic
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materials in mmol of the attached s
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The loading capacities for the macr
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CHAPTER FIVEMETAL ION UPTAKE STUDIE
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Conformer C had never been observed
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ions by Si-GPS-Trac, 43 is in most
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Zn(II); with Pb(II) showing a lesse
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CHAPTER SIXGUEST MOLECULE INCLUSION
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of 100 mg of the host material, Si-
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nitrophenolate inclusion experiment
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HOHOOOsilane linkerN(Z)OH H HO O HO
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It can be seen here that a water mo
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percent inclusion with the pK a val
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contact with an aqueous environment
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HTPE appendages interacting with ea
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6.1.6 Guest inclusion studies with
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naphthoate (pK a = 3.60) and 2-naph
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spectrum for the material was then
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it should be borne in mind that pre
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2A13, 4, 5Anionic GuestHostBHost-Gu
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The logK values obtained for this s
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CHAPTER SEVENEXPERIMENTAL
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10 -3 mol dm -3 solutions in anhydr
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lank containing the relevant solven
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H, m, Ar-H); 7.02-6.93 (3 H, m, Ar-
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para); 127.41 (2 C, Bn, ortho); 115
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The preparation of this compound wa
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The preparation of this compound wa
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For the purpose of spectral charact
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7.10 Synthesis of macrocyclic recep
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1,4,7-tris-((S)-2-hydroxy-3-phenoxy
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1-(benzyloxycarbonyl)-4,7,10-tris(S
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1-(benzyloxycarbonyl)-4,7,10-tris(S
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1-(2-hydroxypropyl)-4,7,10-tris-((S
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[Cd(1-(2-hydroxypropyl)-4,7,10-tris
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Si-GPS-Trac, 4343To a stirred suspe
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silica gel (1.5 g; Merck 60 70 - 23
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Si-GPS-DiPTrac, 4444To a stirred su
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Appendix A
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Rearranging equation 1.4 gives equa
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Appendix B
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The stoichiometry of the product H
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APPENDIX C
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Si-GPS-[Cd(Trac)(o-hydroxybenzoate)
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Si-GPS-[Cd(DiPTrac)(o-hydroxybenzoa
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REFERENCES1. D. J. Cram and J. M. C
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29. K. Muller-Dethlefs and P. Hobza
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54. B. Dietrich, Pure Appl. Chem.,
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81. P. A. Gale, ed., The Encyclopae
- Page 192 and 193:
105. K. E. Borbas and J. I. Bruce,
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131. V. Boldrini, G. B. Giovenzana,
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156. A. Katz, P. Da Costa, A. C. P.
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183. D. M. Corsi, H. van Bekkum and
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209. C. R. Silva, I. C. S. F. Jardi
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236. C. Lopez, R. M. Claramount and