Jozef Hodyl PhD Thesis - Theses - Flinders University

1,4,7-tris(S)-2-hydroxy-3-[4-(2-(2-(2-hydroxyethoxy)ethoxy)-ethoxy)phenoxypropyl]-1,4,7,10-tetraazacyclododecane, 4848Synthesis of this compound was by a method analogous to that used for thepreparation of 46 using 73 (457 mg, 0.39 mmol), and, cyclohexene, 74, (183 mg,2.22 mmol), to give 48 as a thick brown oil, 415 mg, in quantitative yield. 13 C NMR(CD 3 CN): δ 153.15 (1 C, Ph, ipso); 153.090 (1 C, Ph, ipso); 153.05 (1 C, Ph, ipso);152.98 (1 C, Ph, para); 152.91 (1 C, Ph, para); 152.85 (1 C, Ph, para); 115.63 (2 C,Ph); 115.59 (4 C, Ph); 115.48 (6 C, Ph); 72.54 (2 C, -OCH 2 HTPE); 72.51 (1 C, -OCH 2 HTPE); 70.72 (2 C, -OCH 2 HTPE); 70.70 (1 C, -OCH 2 HTPE); 69.78 (3 C, -OCH 2 HTPE); 67.96 (3 C, -OCH 2 HTPE) 61.56 (2 C, -OCH 2 HTPE); 61.50 (1 C, -OCH 2 HTPE); 71.27 (2 C, -OCH 2 ); 70.27 (2 C, -OCH 2 ); 69.66 (2 C, -CH); 69.42 (1C, -CH); 59.00 (2 C, -NCH 2 ); 58.45 (1 C, -NCH 2 ); 50.1 (4 C, cyclen -CH 2 ); 44.05 (4C, cyclen -CH 2 ).143