Jozef Hodyl PhD Thesis - Theses - Flinders University

forces and essentially the whole gamut of intermolecular interactions, previouslymentioned, as part of their anion retention mechanism. 5 Some of these receptor typeswill be discussed in the following pages.1.3.1 CyclodextrinsSince their discovery in 1891 by Villiers 60the exploitation and development ofcyclodextrins has extended into many areas of research. 61In more recent timescyclodextrins have been the focus of considerable studies with regard to their abilityto act as synthetic hosts for guest molecule inclusion using hydrophobic binding. 62-67Cyclodextrins are a class of naturally occurring, toroid-shaped cyclicoligosaccharides the best known of which comprise 6, 7 or 8 D-glucopyranosidesubunits assigned as α-, β- and γ-CD (with internal diameters of 4.7 - 5.3 Å, 6.0 - 6.5Å and 7.5 - 8.3 Å, respectively); and, connected by α-(1,4) linkages, for example β-CD, 7. 627Cyclodextrins have an exceptional ability to form stable 1:1 complexes with a5, 62wide variety of appropriately sized hydrophobic guest species in aqueous media.In 1977 Bergeron and co-workers reported the inclusion of a molecule of either p-8