Jozef Hodyl PhD Thesis - Theses - Flinders University

1-(benzyloxycarbonyl)-4,7,10-tris(S)-2-hydroxy-3-[4-((2-(2-hydroxyethoxy)ethoxy)phenoxypropyl]-1,4,7,10-tetraazacyclododecane, 7272Synthesis of this compound was by a method analogous to that used for thepreparation of 71 using 50 (415 mg, 1.35 mmol) and 59 (1.04 g, 4.08 mmol), to give72 as a thick brown oil, 1.44 g, in quantitative yield. 13 C NMR (CDCl 3 ): δ 156.26 (1C, C=O); 152.95 (3 C, Ph, ipso); 152.77 (3 C, Ph, para); 136.54 (1 C, Bn, ipso);128.29 (1 C, Bn); 127.80 (1 C, Bn); 127.77 (1 C, Bn); 127.70 (2 C, Bn); 115.40 (6 C,Ph); 115.33 (6 C, Ph); 72.46 (3 C, -CH 2 HTPE); 71.23 (1C, -OCH 2 ); 70.42 (1C, -OCH 2 ); 70.30 (1C, -OCH 2 ); 69.47 (3 C, -CH 2 HTPE); 67.86 (3 C, -CH 2 HTPE);66.93 (2 C, -CH); 66.72 (1 C, -CH); 65.98 (1 C, -CH 2 , Bn); 61.28 (3 C, -CH 2 HTPE);59.15 (3 C, -CH 2 N); 52.76 (2 C, cyclen -CH 2 ); 50.05(2 C, cyclen -CH 2 ); 47.50 (2 C,cyclen -CH 2 ); 44.43 (2 C, cyclen -CH 2 ).140