Jozef Hodyl PhD Thesis - Theses - Flinders University

Tetraaza metal complexes immobilised on solid supports have been utilised asbiomimetic catalysts in the hydrolysis of plasmid DNA, 162 phosphodiesters, 163 andproteins. 164 These artificial enzyme systems all consist of a metal complexed cyclenderivative attached to an organic polymeric backbone. An example is the polymerimmobilised Zn 2+ cyclen complex 42 synthesised as an artificial enzyme for cleavageHNNHof phosphodiesters. 163 HO N NZn 2+2ClO 4-H42polymeric support1.5 Aims of the ProjectThe objectives of this project were to explore the inclusion properties, in aqueousconditions, of three-walled, cyclen-based, receptor complexes immobilised on asilica surface. It was thought that this system, shown as 94 would extend thecapabilities of the previously studied four-walled, first generation receptor94, 95complexes, 26, synthesised by Smith.This would entail initial synthesis and exploration of the aromatic anion retentioncapabilities of a non silica attached, three-walled model system which, if successful,would then be anchored onto chromatographic silica gel. Various derivatives withdifferent properties such as wettability in water, 95 and 96 would also be synthesisedand characterised.These silica attached receptor materials would then be subjected to metal ioncomplexation with subsequent inclusion studies involving a range of aromatic33