Jozef Hodyl PhD Thesis - Theses - Flinders University

1-(benzyloxycarbonyl)-4,7,10-tris(S)-2-hydroxy-3-[4-(2-(2-(2-hydroxyethoxy)-ethoxy)ethoxy)phenoxypropyl]-1,4,7,10-tetraazacyclododecane, 73OHOOOHOOHOHOHNNNNOOHOOOOHHOOOOO73HOSynthesis of this compound was by a method analogous to that used for thepreparation of 71 using 50 (503 mg, 1.64 mmol), and 60 (1.50 g, 4.94 mmol), to give73 as a thick brown oil, 1.93 g, in quantitative yield. 13 C NMR (CDCl 3 ): δ 156.18 (1C, C=O); 152.89 (3 C, Ph, ipso); 152.74 (3 C, Ph, para); 136.49 (1 C, Bn, ipso);128.26 ( 1 C, Bn); 127.75 (4 C, Bn); 115.37 (6 C, Ph); 115.27 (6 C, Ph); 72.34 (3 C, -OCH 2 HTPE); 70.47 (3 C, -OCH 2 HTPE); 70.31 (1 C, Bn, -CH 2 ); 70.03 (3 C, -OCH 2HTPE); 69.53 (3 C, -OCH 2 HTPE); 67.76 (3 C, -OCH 2 HTPE); 66.91 (2 C, OCH 2 );66.80 (1 C -OCH 2 ) 66.02 (3 C, -CH); 61.33 (3 C, -OCH 2 HTPE); 59.08 (2 C, -NCH 2 ); 58.00 (1 C, -NCH 2 ); 53.61 (2 C, cyclen CH 2 ); 52.68 (2 C, cyclen CH 2 );50.61 (2 C, cyclen CH 2 ); 47.47 (2 C, cyclenCH 2 ).142