Jozef Hodyl PhD Thesis - Theses - Flinders University

and, more so due to the larger size of these molecules. However, it cannot be arguedthat the reduction in macrocycle loading for these materials is controlled solely bythe accessibility of linker molecules. These two materials contain macrocyclicreceptor ligands that are inherently larger at their periphery and with the dynamicnature of the HTPE appendages there could be an amplification in steric crowding inthe vicinity of the parent nucleophilic centres. These two unfavourable conditionswould in combination contribute to the lower degree of macrocycle loading observedwith the HTPE appended silica materials.86