Oncology Probes

ON CCND1 (BCL1;11q13) BreakBesides the important functions in cellular growth,metabolism, and cellular differentiation, CCND1 (also knownas Cyclin D1 or BCL1) can also function as a proto-oncogene,often dysregulated after re-arrangement by translocation. Infact, it can juxtapose into many different gene locus to drivetumorigenic effects. To date, the gene has been found to berearranged in leukemias, in multiple myelomas (MM), and insome cases of benign parathyroid tumors. More specifically,the chromosomal translocation t(11;14)(q13:q32), involvingrearrangement of the CCND1 locus, has been reported to beassociated with human lymphoid neoplasia affecting mantlecell lymphomas (MCL).The rearrangement has been documented in 40-70% ofcases of mantle cell lymphoma, whereas it only rarely occursin other B cell lymphomas. In multiple myeloma, the sametranslocation t(11;14)(q13:q32) is the most common, witha reported frequency of 15% to 20% of the cases. For thisreason, the CCND1 break apart probe KBI-10609 can beconsidered a very useful tool for routine diagnosis in MCLand Multiple myeloma, to be used in association to therelated probes KBI-10604 and KBI-10605 probes that candetect more specifically the translocation t(11;14) in MantleCell Lymphoma (KBI-10604) and Multiple Myeloma (KBI-10605).Cat.# KBI-10609 CCND1 (BCL1; 11q13) BreakD11S1267630 KB11q13MYEOVGap 440 KB11CCND1510 KBD11S3652CCND1 (BCL1; 11q13) Break probe hybridized to a normalmetaphase (2R2G).Literature:Vaandrager et al, 1996, Blood, 88 (4); 1177-1182Vaandrager et al, 1997, Blood, 89; 349-350Ordering information Color Tests Cat#ON CCND1 (BCL1;11q13) Break red/green 10 KBI-10609Oncology Probes - Hematology Probes43