UROP Proceedings 2010-11

A New Way for Characterization of Chinese MedicineAdvisor : TSIM Karl W K / LIFSStudent : YAU Ka Ho / CHEM(UROP1100, Fall 2010)Health keeping is more than the absence of diseases. The philosophy of traditional ChineseMedicine has its unique capacity of harmonization and enhancement. Chinese medicine is anancient system of health care that underwent continuous development over centuries, as thecauses of illness afflicting mankind evolved over the same period. In order to understand theguiding principles behind Chinese medicine, characterization of their chemical componentsbecome increasingly important. In this project, the first part focused on the properties ofChinese medicine, such as quality and purity. Hence determinations of ash and waterextractives were done. The second part of the project focused on the determination oforganochlorine pesticides. Different analytical methods such as GC-ECD, GPC and SPE wereused to determine the organochlorine pesticides in the studied samples of Chinese medicines.Mapping the Interaction Domains and Interaction Partners of MCM10in Pre-replication Complex AssemblyAdvisorCo-AdvisorStudent: TYE Bik Kwoon YEUNG / LIFS: LIANG Chun / LIFS: ZHU Lin / BICH(UROP1000, Summer 2011)In every cell division, each cell must replicate its genome and pass it to its daughter cells.Generally, the replication of the genome can be divided into two stages. The first stage isknown as replication licensing, a multi-protein complex is loaded onto specific sites in thegenome to form the pre-replication complex (pre-RC). The second stage begins after theloading of pre-RC in G 1 , when two protein kinases, CDK and DDK, phosphorylatecomponents of the pre-RC to activate the pre-RC. Of the many proteins assembled in pre-RC,MCM10 plays a critical role in coordinating this transition, and it is the focus of this project.8