Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

1.2 Anaphylaxis medications should be available1.2.1 Epinephrine 0.2-0.5 mg IM or SC Q5 minutes as needed1.2.1.1 Pediatrics: 0.01 mg/kg (maximum 0.3mg)1.2.2 Diphenhydramine 25-50 mg IV1.2.2.1 Pediatrics: 1-2 mg/kg1.2.3 Albuterol 2.5-5 mg nebulizedF. Patient Interview1.0 Potential questions to ask a patient/family member when investigating a medicationallergy include: 61.1 Patient’s age at the time of the reaction1.2 Patient’s recall of the reaction or who informed them of it1.3 Time of onset of the reaction after beginning the penicillin (e.g., after 1 dose orseveral days)1.4 Signs/symptoms of the reaction1.4.1 Was an antidote given1.4.2 Did it require a visit to emergency room1.4.3 Was there a loss of consciousness1.5 Route of administration (oral or IV)1.6 Indication for penicillin (or cephalosporin)1.7 Concurrent medications1.8 Did the reaction abate after the penicillin (or cephalosporin) was discontinued1.9 Had the patient taken other penicillins (or cephalosporins) before or after thereaction1.9.1 If yes, what was the outcomeReferences1. Solensky R, Earl H, Gruchalla RS. Clinical approach to penicillin-allergic patients: asurvey. Ann Allergy Asthma Immunol 2000;84:329-33.2. Solensky R. Drug desensitization. Immunol Allergy Clin N Am 2004;24:425-43.3. Park MA, Li JTC. Diagnosis and management of penicillin allergy. Mayo Clin Proc2005;80:405-10.4. Pichichero ME. A review of evidence supporting the American Academy of Pediatricsrecommendations for prescribing cephalosporin antibiotics for penicillin-allergicpatients. Pediatrics 2005;115:1048-57.5. Gruchalla RS, Pirmohamed M. Antibiotic allergy. NEJM 2006;354:601-9.6. Salkind AR, Cuddy PG, Foxworth JW. Is this patient allergic to penicillin? Anevidence-based analysis of the likelihood of penicillin allergy. JAMA 2001;285:2498-505.7. Bernstein IL, et al. Executive summary of disease management of drughypersensitivity: a practice parameter. Ann Allergy Asthma Immunol 1999;83:665-700.8. Puchner TC, Zacharisen MC. A survey of antibiotic prescribing and knowledge ofpenicillin allergy. Ann Allergy Asthma Immunol 2002;88:24-9.9. Gallelli JF, Calis KA. Penicillin allergy and cephalosporin cross-reactivity. HospPharm 1992;27:540-1.10. Grabenstein JD. Predicting allergy to penicillin: a decision maker’s dilemma. HospPharm 1993;28:1020-5.11. Robinson JL, Hameed T, Carr S. Practical aspects of choosing an antibiotic forpatients with a reported allergy to an antibiotic. CID 2002:35:26-31.12. MacLaughlin EJ, et al. Cost of beta-lactam allergies. Arch Fam Med 2000;9:722-6.13. Sade K, et al. The economic burden of antibiotic treatment of penicillin-allergicpatients in internal medicine wards of a general tertiary care hospital. Clin Exp Allergy2003;33:501-6.