Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

RIFAMPINUse of rifampin for injection requires Infectious Diseases approval (See Appendix I)Usual DoseAdult: 600 mg Q12-24H PO/IV (UWHC cost/day PO $1.94-3.88; IV $36.72-73.44);Endocarditis: 300 mg PO/IV TID (UWHV cost/day PO $2.91; IV $55.08)IV formulation requires ID approval.Pediatric:** Treatment 10-20 mg/kg/day PO/IV in divided doses Q12-24H.Indications1. Active tuberculosis, always as part of a multiple drug regimen.2. Latent tuberculosis infection treatment, in combination with pyrazinamide (treat for 2 months). Not currentlyrecommended by CDC.3. Meningococcal prophylaxis, in persons with close exposure to Neisseria meningitidis. (600 mg BID PO x two days).Second-line therapy.4. Methicillin-resistant coagulase-negative Staphylococcus valvular endocarditis or CNS shunt infections, in combinationwith vancomycin and gentamicin.5. Haemophilus influenzae meningitis prophylaxis. Drug of choice in pediatrics, second-line agent in adults. Drug of choicein adults is ciprofloxacin.Dosing in adults: 600 mg daily PO x four doses.Dosing in children: (>1 month) 20 mg/kg/day PO x 4 doses (maximum 600 mg daily)Dosing in patients