Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

D. Dose of Antibiotic1. Piperacillin/tazobactam 7Estimated CrClDose> 20 ml/min 3.375G IV Q8H infused over 4 hours< 20 ml/min and HD/PD patients 3.375G IV Q12H infused over 4 hours2. MeropenemAll patients prescribed meropenem will initially receive 500mg IV every 6 hours infused over 3hours (adjusted based on renal function). IF after 72 hours no organism is recovered or theorganism recovered has an MIC that is ≤ 2 mcg/ml, the dose of meropenem will be dose reducedto 500mg IV every 8 hours infused over 3 hours (adjusted based on renal function). IF organismswith an MIC > 2 mcg/ml are recovered, the meropenem dose will be kept at every 6 hours infusedover 3 hours (adjusted based on renal function) until the meropenem is discontinued. Thispractice will ensure that organisms with higher MICs are appropriately treated prior toidentification.Estimated CrCl Initial Dosing Deescalated Dosing> 36 500mg IV Q6H over 3 hours 500mg IV Q8H over 3 hours26-35 500mg IV Q8H over 3 hours 500mg IV Q8H over 3 hours10-25 500mg IV Q12H over 3 hours 500mg IV Q12H over 3 hours