Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

superinfection: amoxicillin 1 g PO TIDfor 10 days or amoxicillin/clavulanateextended-release two tablets PO BIDfor 10 days ($)Acute BacterialSinusitis 23 Amoxicillin 500 mg PO TID for 10 days -Antibiotic therapy should bereserved for patients withmoderately severe symptomslasting at least 7-10 days whohave maxillary pain ortenderness in face or teeth(symptomatic treatmentpreferred for patients with mildsymptoms)Skin InfectionsImpetigo 24,25Mild to ModerateInflammatory Acne 26Inflammatory Acne 26Severe PapulonodularAcne 26Topical mupirocin 2% TID for 7 days($)Topical benzoyl peroxide 5% pluserythromycin 2% solution applied BIDfor 8-12 weeksTopical benzoyl peroxide 5% pluserythromycin 2% solution applied BIDfor 8-12 weeks or oral tetracycline 500mg BID for 6-8 weeks (preferred) ordoxycycline 100 mg PO BID for 6-8weeksNo anti-infective strategies suggested-Treatment continued until nonew lesions develop and thenshould be slowly discontinued-Use OTC benzoyl peroxideand generic topicalerythromycin preparationEarly Lyme Disease 27,28 Doxycycline 100 mg PO BID for 10days-Therapeutic choice isappropriate for the treatmentof early localized or earlydisseminated Lyme diseaseassociated with erythemamigrans, in the absence ofneurological involvement orthird-degree atrioventricularheart block