Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

• Chloramphenicol • Leflunomide • Saquinavir*• Chlorpropamide • Levothyroxine • Sertraline• Citalopram • Linezolid • Sirolimus• Clofibrate • Lopinavir* • Sorafenib• Clozapine • Lorcainide • Sunitinib• Corticosteroids • Losartan • Tacrolimus• Cyclosporine • Maraviroc • Tadalafil• Dapsone • Medroxyprogesterone • Tamoxifen• Darunavir* • Mefloquine • Telithromycin• Dasatinib • Methadone • Temsirolimus• Deferasirox • Metoprolol • Terbinafine• Delavirdine • Mexiletine • Theophylline• Diazepam • Midazolam • Tinidazole• Digoxin • Mifepristone • Tipranivir*• Diltiazem • Monteleukast • Tocainide• Disopyramide • Morphine • Tolbutamide• Doxycycline • Moxifloxacin • Tolvaptan• Dronaderone • Mycophenolate • Tramadol• Efavirenz • Nelfinavir • Triazolam• Erlotinib • Nevirapine • Trimetrexate• Estazolam • Nifedipine • Valproic acid• Eszopiclone • Nilotinib • Verapamil• Estrogens • Nisoldipine • Voriconazole*• Etravirine • Oral Contraceptives • Warfarin• Everolimus • Oxycodone • Zaleplon• Fentanyl • Pazopanib • Zidovudine• Fesoterodine • Pioglitazone • ZolpidemMiscellaneous drug interactions with rifampin are as follows:• Bosentan – trough level is initially increased, then at steady state blood levels are decreased• Carbamazepine – rifampin may inhibit its metabolism, resulting in increased blood levels• Eltrombopag – is an OATP1B1 inhibitor that is in turn inhibited by rifampin; concurrent administration of anOATP1B1 substrate results (for example, rosuvastatin) results in increased blood levels of the substrate• Enalapril – decreased efficacy due to increased clearance of active metabolite• Entacapone – increased blood levels due to interference with biliary secretion• Ethionamide – increased risk of hepatotoxicity• Levomethadyl – increased risk of QT prolongation, torsades de pointes• Probenecid – increases rifampin blood levels• Valsartan – increased blood levels due to OATP1B1 inhibition by rifampin