Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

Empiric coverage for Enterococcus is recommended; give full course of therapy iffound in cultures:• Ampicillin• Piperacillin/tazobactam• VancomycinEmpiric coverage for VRE is not routinely recommended unless the patient isknown to be colonized with VRE and moderately ill, or extremely high risk forVRE, e.g., liver transplant patient with sepsis in the ICU. Coverage would usuallybe for 72 hours to rule out VRE.Empiric coverage for MRSA is indicated for patients known to be colonized withMRSA:• Vancomycin• Daptomycin*• Linezolid*o *- ID restrictedEmpiric coverage for yeast may be appropriate, especially if yeast is seen on theGram stain; give full course of appropriate therapy if found in cultures:• Fluconazole• Micafungin*o *ID-restrictedo For non-albicans yeastF. Cholangitis, Cholecystitis and Appendicitis• In general, cholangitis and cholecystitis follow recommendations for thethree categories of infections• Anaerobic coverage is not mandatory unless there is a biliary-entericanastomosis• Routine coverage for Enterococcus is not required except for livertransplant patients• Antibiotics should be discontinued within 24 hours unless there is evidenceof infection outside the gallbladder• In general, appendicitis should follow recommendations for communityacquiredinfectionsG. Duration of TherapyThe following recommendation is taken directly from the published guideline:Evidence presented in the previous guidelines suggested that a duration oftherapy no greater than 1 week was appropriate for most patients with intra-