Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

TELITHROMYCINUsual DoseAdult: 800 mg Q24H PO (UWHC cost/day $9.26)Indications1.Community-acquired pneumonia of mild-to-moderate severity caused by proven or highly suspected multidrug-resistantS pneumoniaeCommentsTelithromycin may only be used where penicillin or macrolide-resistant pneumococci are suspected as infectious agents.Drug InteractionsTelithromycin inhibits the CYP450 3A4 enzyme, causing many drug-drug interactions with other drugs that aremetabolized by that enzyme system. The use of telithromycin is contraindicated in patients taking pimozide or cisapride.Serum levels of statin drugs, digoxin, theophylline and alprazolam may become elevated with concomitant use oftelithromycin. Itraconazole and ketoconazole increase serum levels of telithromycin. Concomitant administration ofrifampin significantly decreases serum levels of telithromycin. Several cases of severe liver toxicity have been reported inpatients taking telithromycin, which led the FDA to retract all but one indication for use in 2007.TENOFOVIRAlso a component of the combination product Truvada ® .For up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/TENOFOVIR/EMTRICITABINE (Truvada ® ) – non-formulary at UWHCFor up-to-date information on the use of antiretrovirals, consult an HIV expert or www.aidsinfo.nih.gov/Please verify the indication for use; continuation of pre-exposure prophylaxis for inpatients may not be appropriate.TETRACYCLINEUsual DoseAdult: 250-500 mg Q6H PO OR 500 mg Q12H PO (UWHC cost/day $0.10-0.21).Pediatric:** 25-50 mg/kg/day PO in divided doses Q6H (not for children