Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

Community-AcquiredPneumonia 21,22-Previously healthy patient given norecent antibiotic therapy: doxycycline100 mg PO BID for 10-14 days orerythromycin 500 mg PO BID for 10-14 days-Previously healthy patient givenrecent antibiotic therapy: respiratoryquinolone ($) or advanced macrolideand beta-lactam ($) or telithromycin800 mg PO daily for 7-10 days ($)-Patient with comorbidities (COPD,diabetes, renal or congestive heartfailure, or malignancy) given no recentantibiotic therapy: respiratoryquinolone ($) or advanced macrolide($) or telithromycin 800 mg PO dailyfor 7-10 days ($)-Patient with comorbidities givenrecent antibiotic therapy: respiratoryquinolone ($) or advanced macrolideand beta-lactam ($) or telithromycin800 mg PO daily for 7-10 days ($)-Suspected aspiration with infection:clindamycin 300 mg PO four timesdaily for 10 days ($) oramoxicillin/clavulanate extendedreleasetwo tablets PO BID for 10days ($)-Influenza with bacterialor more of the followingsymptoms: history of fever,tonsillar exudates, no cough,and tender anterior cervicallymphadenopathy 19-Group A streptococcalpharyngitis is usually selflimitingwith symptomsdisappearing spontaneouslywithin 3-4 days of onset, evenwithout antibiotics 19-Antibiotic therapy can safelybe postponed for up to 9 daysafter onset of symptoms andstill prevent occurrence of themajor nonsuppurativesequela, acute rheumaticfever 19-Respiratory quinolones are• Levofloxacin 750 mgPO daily for 5 days• Or moxifloxacin 400mg PO daily for 10days-Advanced macrolides are• Azithromycin 500 mgPO on day one then250 mg PO daily ondays 2-5• Or clarithromycin 500mg PO BID for 10-14days-Beta-lactams are• Amoxicillin 1 g PO TIDfor 10 days• Amoxicillin/clavulanateextended-release(Augmentin XR ® ) twotablets PO BID for 10days (equals 2 g ofamoxicillin plus 125mg clavulanate perdose)