Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

APPENDIX C: THERAPY FOR TUBERCULOSIS IN THE ERA OF MULTIDRUG RESISTANCEThis Official Joint Statement of the American Thoracic Society, CDC, and the Infectious Diseases Society of America wasapproved by the ATS Board of Directors, by CDC, and by the Council of the IDSA in October 2002. This report appeared in theAmerican Journal of Respiratory and Critical Care Medicine (2003;167:603--62) and is being reprinted as a courtesy to theAmerican Thoracic Society, the Infectious Diseases Society of America, and the MMWR readership.The complete treatment document can be found at http://www.cdc.gov/mmwr/preview/mmwrhtml/rr5211a1.htmTable 1 Dose* of antituberculosis drugs for adults and children†Drug Preparation Adults/ChildrenFirst-line drugsIsoniazid Tablets (50 mg, 100mg, 300 mg); elixir(50 mg/5 mL);aqueous solution(100 mg/mL) forintravenous orintramuscularRifampininjectionCapsule (150 mg,300 mg); powdermay be suspendedfor oraladministration;aqueous solution forintravenous injectionAdults (max.)Children (max.)Adults‡ (max.)Children (max.)Rifabutin Capsule (150 mg) Adults‡ (max.)DosesDaily 1x/wk 2x/wk 3xwk5 mg/kg (300 mg)10-15 mg/kg (300 mg)15 mg/kg (900 mg)--15 mg/kg (900 mg)20-30 mg/kg (900 mg)15 mg/kg (900 mg)--10 mg/kg (600 mg)--10 mg/kg (600 mg) 10 mg/kg (600 mg)10-20 mg/kg (600 mg)--10-20 mg/kg (600 mg)--5 mg/kg (300 mg)--5 mg/kg (300 mg) 5 mg/kg (300 mg0RifapentineTablet (150 mg, filmcoated)ChildrenAdultsAppropriate dosing forchildren is unknown--Appropriate dosing forchildren is unknown10 mg/kg (continuationphase) (600 mg)Appropriate dosing forchildren is unknown--Appropriate dosing forchildren is unknown--ChildrenThe drug is not approved The drug is not The drug is not approved The drug is notfor use in children approved for use in for use in children approved for use inchildrenchildrenPyrazinamide Tablet (500 mg, Adults See Table 2 -- See Table 2 See Table 2