Antimicrobial Use Guidelines (AMUG) version 21 - UW Health

CardiothoracicLIKELYPATHOGENSANTIMICROBIAL REGIMEN(Adult)ANTIMICROBIAL REGIMEN(Pediatric)OR REDOSINGCOMMENTSGeneralCardiothoracicCoagulase-negativestaph, Staph aureus,Corynebacterium,enteric Gram--negativebacilli.• Cefuroxime 4,5 1.5 g IV preop• AND/OR vancomycin 1 gIV (single dose) ifimplantation ofprosthetic/valvular graft(Staphylococcusepidermidis), or if patient isMRSA-positive• Cefuroxime 30mg/kg IVpreop (Maximum of 1.5 g)• AND/OR vancomycin15mg/kg IV (Maximum of1g) if patient is MRSApositiveor if penicillinallergic• Cefuroxime every 4hours or at end ofcardiopulmonarybypass.• Vancomycin: none;every 6 hours forpediatric patientsCefuroxime has enhanced activityagainst coagulase-negativestaphylococci----- or• Vancomycin 1 g IV, ifpenicillin allergicLeft VentricularAssist Device• Rifampin 600 mg POplusCiprofloxacin 400 mg IVFluconazole 400 mg IVVancomycin 15 mg/kg (upto 1 g) IV• • Ciprofloxacin every12 hours• Fluconazole every12 hours• Vancomycin every12 hoursLungtransplant:Cystic Fibrosispatient• Check Infectious DiseaseRecommendationsCheck Infectious DiseaseRecommendations