17. Maertens J, Glasmacher A, Herbrecht R, Thiebaut A, Cordonnier C, Segal BH, Killar J,Taylor A, Kartsonis N, Patterson TF. Multicenter, noncomparative study of caspofunginin combination with other antifungals as salvage therapy in adults with invasiveaspergillosis. Cancer 2006;Published online 11/13/2006.18. Wingard JR. Lipid formulations of amphotericins: are you a lumper or a splitter? ClinInfect Dis 2002;35(7):891-5.19. Leenders AC. Reiss P. Portegies P. Clezy K. Hop WC. Hoy J. Borleffs JC. Allworth T.Kauffmann RH. Jones P. Kroon FP. Verbrugh HA. de Marie S. Liposomal amphotericin B(AmBisome) compared with amphotericin B both followed by oral fluconazole in thetreatment of AIDS-associated cryptococcal meningitis. AIDS 1997;11(12):1463-71.20. Bennett JE. Dismukes WE. Duma RJ. Medoff G. Sande MA. Gallis H. Leonard J. FieldsBT. Bradshaw M. Haywood H. McGee ZA. Cate TR. Cobbs CG. Warner JF. Alling DW. Acomparison of amphotericin B alone and combined with flucytosine in the treatment ofcryptococcal meningitis. N Engl J Med 1979;301(3):126-31.<strong>21</strong>. Sobel J. Practice guidelines for the treatment of fungal infections. Clin Infect Dis2000;30(4):652-70.22. Saag MS. Powderly WG. Cloud GA. Robinson P. Grieco MH. Sharkey PK. ThompsonSE. Sugar AM. Tuazon CU. Fisher JF. et al. Comparison of amphotericin B withfluconazole in the treatment of acute AIDS-associated cryptococcal meningitis. TheNIAID Mycoses Study Group and the AIDS Clinical Trials Group. N Engl J Med1992;326(2):83-9.23. van Duin D, Cleare W, Zaragoza O, Casadevall A, Nosanchuk JD. Effects ofvoriconazole on Cryptococcus neoformans. Antimicrob Agents Chemother 2004;48:2014-20.24. Powderly WG. Saag MS. Cloud GA. Robinson P. Meyer RD. Jacobson JM. Graybill JR.Sugar AM. McAuliffe VJ. Follansbee SE. et al. A controlled trial of fluconazole oramphotericin B to prevent relapse of cryptococcal meningitis in patients with the acquiredimmunodeficiency syndrome. The NIAID AIDS Clinical Trials Group and Mycoses StudyGroup. N Engl J Med 1992;326(12):793-8.25. Pfaller MA. Messer SA. Hollis RJ. Jones RN. SENTRY Participants Group. Antifungalactivities of posaconazole, ravuconazole, and voriconazole compared to those ofitraconazole and amphotericin B against 239 clinical isolates of Aspergillus spp. andother filamentous fungi: report from SENTRY <strong>Antimicrobial</strong> Surveillance Program, 2000.Antimicrob Ag Chemother 2002;46(4):1032-7.26. Wheat J, Sarosi G, McKinsey D, Hamill R, Bradsher R, Johnson P, Loyd J, Kauffman C,Practice guidelines for the management of patients with histoplasmosis. InfectiousDiseases Society of America. Clin Infect Dis 2000;30:688-95.27. Torres HA, Hachem RY, Chemaly, Kontoyuannus DP, Raad II. Posaconazole: a broadspectrum triazole antifungal. Lancet Infec Dis 2005;5:775-8528. Greenberg RN, Mullane K, vanBurik JA, Raad I, Abzug MJ, Anstead G, Herbrecht R,Langston A, Marr KA, Schiller G, Schuster M, Wingard JR, Gonzalez CE, Revankar SG,Corcoran G, Kryscio RJ, Hare R. Posaconazole as salvage therapy for zygomycosis.Antimicrob Agents Chemother 2006;50:126-133.29. Gotzsche, PC. Johansen, HK. Routine versus selective antifungal administration forcontrol of fungal infections in patients with cancer. Cochrane Gynaecological CancerGroup. Cochr Database System Rev 2003; 1.30. Walsh TJ. Finberg RW. Arndt C. Hiemenz J. Schwartz C. Bodensteiner D. Pappas P.Seibel N. Greenberg RN. Dummer S. Schuster M. Holcenberg JS. Liposomalamphotericin B for empirical therapy in patients with persistent fever and neutropenia.National Institute of Allergy and Infectious Diseases Mycoses Study Group. N Engl J Med1999;340(10):764-71.31. Wingard JR. White MH. Anaissie E. Raffalli J. Goodman J. Arrieta A. LAmph/AMPHOTERICIN B LIPID COMPLEX Collaborative Study Group. A randomized,double-blind comparative trial evaluating the safety of liposomal amphotericin B versusamphotericin B lipid complex in the empirical treatment of febrile neutropenia. L
Amph/AMPHOTERICIN B LIPID COMPLEX Collaborative Study Group. Clin Infect Dis2000;31(5):1155-63.32. Winston DJ. Hathorn JW. Schuster MG. Schiller GJ. Territo MC. A multicenter,randomized trial of fluconazole versus amphotericin B for empiric antifungal therapy offebrile neutropenic patients with cancer. Am J Med 2000;108(4):282-9.33. Boogaerts M. Winston DJ. Bow EJ. Garber G. Reboli AC. Schwarer AP. Novitzky N.Boehme A. Chwetzoff E. De Beule K. Itraconazole Neutropenia Study Group.Intravenous and oral itraconazole versus intravenous amphotericin B deoxycholate asempirical antifungal therapy for persistent fever in neutropenic patients with cancer whoare receiving broad-spectrum antibacterial therapy. A randomized, controlled trial. AnnIntern Med 2001;135(6):412-22.34. Persistent fever in patients with neutropenia. N Engl J Med 2002;346(4):222-4.35. Walsh TJ. Pappas P. Winston DJ. Lazarus HM. Petersen F. Raffalli J. Yanovich S. StiffP. Greenberg R. Donowitz G. Schuster M. Reboli A. Wingard J. Arndt C. Reinhardt J.Hadley S. Finberg R. Laverdiere M. Perfect J. Garber G. Fioritoni G. Anaissie E. Lee J.National Institute of Allergy and Infectious Diseases Mycoses Study Group. Voriconazolecompared with liposomal amphotericin B for empirical antifungal therapy in patients withneutropenia and persistent fever. N Engl J Med 2002;346(4):225-34.36. Powers JH. Dixon CA. Goldberger MJ. Voriconazole versus liposomal amphotericin B inpatients with neutropenia and persistent fever. N Engl J Med 2002;346(4):289-90.37. Walsh TJ, Teppler H, Donowitz GR, Maertens JA, Baden LR, Dmoszynska A, CornelyOA, Bourque MR, Lupinacci RJ, Sable CA, dePauw BE. Caspofungin versus liposomalamphotericin B for empirical antifungal therapy in patients with persistent fever andneutropenia. N Engl J Med 2004;351:1391-402.38. Klastersky J. Antifungal therapy in patients with fever and neutropenia – more rationaland less empirical? N Engl J Med 2004;351:1445-6.39. Pfaller MA, Diekema DJ. Rare and emerging opportunistic fungal pathogens: Concern forresistance beyond Candida albicans and Aspergillus fumigatus. J Clin Microbiol2004;42:4419-31.40. Goodman JL. Winston DJ. Greenfield RA. Chandrasekar PH. Fox B. Kaizer H. ShadduckRK. Shea TC. Stiff P. Friedman DJ. et al. A controlled trial of fluconazole to preventfungal infections in patients undergoing bone marrow transplantation. N Engl J Med1992;326(13):845-51.41. Slavin MA. Osborne B. Adams R. Levenstein MJ. Schoch HG. Feldman AR. Meyers JD.Bowden RA. Efficacy and safety of fluconazole prophylaxis for fungal infections aftermarrow transplantation--a prospective, randomized, double-blind study. J Infect Dis1995;171(6):1545-52.42. Marr KA. Seidel K. White TC. Bowden RA. Candidemia in allogeneic blood and marrowtransplant recipients: evolution of risk factors after the adoption of prophylacticfluconazole. J Infect Dis 2000;181(1):309-16.43. Winston DJ. Maziarz RT. Chandrasekar PH. Lazarus HM. Goldman M. Blumer JL. LeitzGJ. Territo MC. Intravenous and oral itraconazole versus intravenous and oralfluconazole for long-term antifungal prophylaxis in allogeneic hematopoietic stem-celltransplant recipients. A multicenter, randomized trial. Ann of Intern Med2003;138(9):705-13.44. Bow EJ. Laverdiere M. Lussier N. Rotstein C. Cheang MS. Ioannou S. Antifungalprophylaxis for severely neutropenic chemotherapy recipients: a meta analysis ofrandomized-controlled clinical trials. Cancer 2002;94(12):3230-46.45. vanBurik JA, Ratanathorn V, Stepan DE, Miller CB, Lipton JH, Vesole DH, Bunin N, WallDa, Heimenz JW, Satoi Y, Lee JM, Walsh TJ, Narional Institute of Allergy and InfectiousDisease Mycoses Study Group. Micafungin versus fluconazole for prophylaxis againstinvasive fungal infections during neutropenia in patients undergoing hematopoietic stemcell transplantation. Clin Infect Dis 2004;39:1407-1416.46. Courtney R, Sudhakar P, Laughlin M, Lim J, Batra V. Pharmacokinetics, safety, andtolerability of oral posaconazole administered in single and multiple doses in healthadults. Antimicrob Agents Chemother 2003;47:2788-2795.
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PREFACEThe Antimicrobial Use Guidel
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Antimicrobial Cost Table (Cost info
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Summary of Antibiotic Order Form: S
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LUNGS/PULMONARYCommunity-Acquired P
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PART I: BY DRUGABACAVIRFor up-to-da
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constructed systemic-pulmonary shun
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AMPICILLIN/SULBACTAM (Unasyn ® )Us
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ATOVAQUONE/PROGUANIL (Malarone ® )
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CEFAZOLINUsual DoseAdult: Moderate/
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CommentsDose adjustment required fo
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1. Typhoid fever. (NOTE: Third-gene
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-Dutasteride-Eltrombopag-Theophylli
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CLINDAMYCINUsual DoseAdult: 600-900
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DAPTOMYCINInfectious Disease approv
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Concurrent administration with peni
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• Cisapride (contraindicated) •
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• Oral contraceptives/hormones -
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Synergy in infective endocarditis a
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• Colchicine • Indinavir • Ta
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- Page 44 and 45: with linezolid should be considered
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- Page 48 and 49: MOXIFLOXACINLevofloxacin and moxifl
- Page 50 and 51: Indications1. Uncomplicated cystiti
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- Page 54 and 55: PIPERACILLIN/TAZOBACTAM (Zosyn ® )
- Page 56 and 57: PRIMAQUINEUsual DoseAdult: Malaria
- Page 58 and 59: RIFABUTINUsual DoseAdult (150 mg ca
- Page 60 and 61: • Chloramphenicol • Leflunomide
- Page 62 and 63: SULFISOXAZOLENo longer available as
- Page 64 and 65: TICARCILLIN/CLAVULANATE (Timentin
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- Page 68 and 69: VANCOMYCINUsual DoseAdult: 1 g Q12H
- Page 70 and 71: Careful monitoring of patients usin
- Page 72 and 73: APPENDIX B: UWHC SURGICAL ANTIMICRO
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- Page 90 and 91: D. Cost ComparisonDrugAmphotericin
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- Page 112 and 113: with aztreonam and other beta-lacta
- Page 114 and 115: D. Side Chains1.2.5. The prescriber
- Page 116 and 117: 14. Pichichiro ME. Use of selected
- Page 118 and 119: Appendix KUWHC Guidelines for Cost-
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- Page 122 and 123: superinfection: amoxicillin 1 g PO
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- Page 128 and 129: D. CategorizationPatients should be
- Page 130 and 131: Empiric coverage for Enterococcus i
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- Page 134 and 135: Bone or JointEndocarditis 4Streptoc
- Page 136 and 137: Candidemia or candidiasis 11Non-neu
- Page 138 and 139: 11. Pappas PG, Kauffman CA, Andes D
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D. Dose of Antibiotic1. Piperacilli
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TNAVasopressinVoriconazoleMeropenem
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pretreatment with an H1-histamine b
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formal consult is not required, but
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K. References1.0 Bliziotis IA, Ples