INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

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2. Multifunctional materials and nanocomposites - PCHARACTERIZATION OF SOME HYBRI<strong>DE</strong> MATERIALS TYPE ENOXYL/CLAYGonţa Alexandru, Lupaşcu 1* Tudor, Popovici 2 Eveline, Hristodor ClaudiaInstitute of Chemistry, Academy of Sciences of Moldova, 3 Academiei str.,MD 2028,Chisinau, Republic of Moldova *E-mail: lupascut@gmail.comAlexandru Ioan Cuza University, Faculty of Chemistry, 11 Carol I Bulevard, 700506, Iasi,RomaniaIn recent decades there is an increasing trend of using wine products, separated byextraction in order to obtain therapeutically efficient products. Enoxyl is a biocompatiblecomplex, patented by the Academy of Sciences of Moldova, produced by chemicalmodification of grape seed extracted enotannins. 1 The physico-chemical analysis showed thatEnoxyl is very hygroscopic compound,. For this purpose this research is an investigation onimproving the physico-chemical properties of drug Enoxyl with the use of new compositeclay. The main goal of this research is to obtain and characterize hybrid materialsEnoxyl / clay, obtained by encapsulation of Enoxyl in montmorillonite cationic type clay, forpharmaceutical use. The impregnation method at room temperature was used.Structural and morphological characterization of materials was performed usingnitrogen adsorption isotherms, which allowed studying the specific surface area and porevolume.Figure 1. Nitrogen adsorption isotherms at 77kfor the studied samples: a-clay (EA), b-Enoxyl(En), c-Enoxyl/clay (Ae-En)General shape of the isotherm, according to IUPAC type IV 2 isotherm, is characteristicto porous adsorbents. Emergence of differences in terms of porosity characteristics afterencapsulation of Enoxyl between clay layers indicates that the encapsulation process tookplace. The isotherm specific for the Enoxyl encapsulated in the clay has a deformed hysteresisloop which leads to broad distributions of pore size, with extremely uneven pore sizes.The material obtained should be regarded as hybrid organic-inorganic nanomaterial withpotential applications in cosmetic and pharmaceutical industries due to its antioxidant andantibacterial properties.References:1. Lupascu, T. and Lupascu, L. (2006) The obtaining procedure of the water soluble enotannins.Patent Nr. 3125. MD. BOPI: 8.2. IUPAC Recommendations Pure Appl. Chem. 1994, 66, 1739
2. Multifunctional materials and nanocomposites - PPRUSSIAN BLUE MODIFIED SCREEN-PRINTED ELECTRO<strong>DE</strong>SFlorentina Hutanu 1, 2 , Emilia Ocnaru 2 , Melania-Liliana Arsene 2 , Gelu Vasilescu 2 ,Mihaela Badea-Doni 21 ’ Stefan cel Mare’ University of Suceava - Universitatii 13, 720229 Suceava, Romania, tel.0230 216147, fax 0230 520267. e-mail: florentinah@fia.usv.ro2National Institute for Research & Development in Chemistry & Petrochemistry, 202 Spl.Independentei 060021, Bucuresti, Romania, tel.021-315.32.99, fax: 021-312.34.93,e-mail: mihaela.badea@icechim.ro; ocnaru.emilia@ icechim.roBy modifying an electrode surface with Prussian Blue, it is possible to easily detect hydrogenperoxide at an applied potential around 0.0 V versus Ag/AgCl, thus making possible couplingwith oxidase enzymes while also avoiding or reducing electrochemical interferences. Inaddition, the use of Prussian Blue in the development of biosensors for food analysis hascaptured the interest of many research groups and led to improved methods for the detectionof glutamate, galactose, alcohol, fructosyl amine, formate, lysine and oxalate [1].A comparative study regarding different procedures for modifying the carbon screen-printedelectrodes (SPE) with Prussian Blue (PB) was carried out in this work. Several procedure forPB deposition on the SPE electrodes were tested: electrochemical deposition (galvanostatic,cyclic voltammetry) and chemical deposition by the reaction of K 3 [Fe(CN) 6 ] with FeCl 3 [2].Also, the influence of the pretreatment of SPE (+1.7V for 3 min in PBS, pH 7.4) and of thestabilization of PB deposited on SPE (by heating at 100°C) were evaluated.The developed sensors were optimized with respect to the lowest limit of detection achievedfor amperometric detection of H 2 O 2 . Analytical parameters, such as detection limit, linearityrange and sensitivity have been evaluated, together with operational and storage stability.[1] F. Ricci, G. Palleschi, Biosens. Bioelectron. 21 (2005) 389-407[2] F. Ricci, G. Paleschi, D. Moscone, Biosens. Bioelectron. 18 (2003) 165 - 174
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INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

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