INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

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3. Chemistry in medical and pharmaceutical applications - OCERCETAREA COMPOZITIEI CHIMICE A FRUCTELOR, FRUNZELOR SI ARAMURILOR TINERE CU MUGURI SI FLORI DE PADUCEL, DIN ZONABALCANICA SI ROMANIA, IN VEDEREA VALORIFICARII LORMAI EFICIENTE IN FITOTERAPIE1 MANEA Stefan, Viorica TAMAS, Mihaela NEAGU, Gina TRAISTARU, AndreeaCOZEA,2 Elda MARKU, Lulezim SHUKA1 S.C. HOFIGAL EXPORT IMPORT S.A. 1 Intrarea Serelor nr.2, sector 4, Bucharest,Romania, Research and Development Departament2 TIRANA University, Faculty of Natural Science, Boulevardi “Zougu I, Tirana, AlbaniaIn the context of the importance of phytotherapy, but also due to climate changes andincreased pollution, the quality of medicinal plants as raw material is essential. The authors of thestudy chose hawthorn (Crataegus monogyna) spontaneous flora from Albania and Romania, asone of the most used herbs for the cardiovascular and nervous system. Considering Albania ashaving a favourable Balkan climate, we have researched in parallel the same organs of Crataegusmonogyna from both countries, collected in 2011, dried in controlled conditions (max 40˚C)finely ground and analysed in terms of their main phytotherapeutic compounds.The main phytotherapeutic compounds determined were: total flavones, anthocyans andproanthocyans, polyphenolcarboxylic acids, tannins, ascorbic acid, crataegic and ursolic acids,and two groups of enzymes - (oxido-reductases and hydrolases). The antioxidant activity was alsodeterminated and as essential nutrients (total proteins, lipids, carbohydrates, minerals).The methods used are in the current edition of Ph. Eur and Ph. Rom X th ed. and for theidentification of other compounds we used chromatographic methods (TLC) and methods ofdosing of chemicals pesticides (HPLC). Much interesting data was obtained from this complexstudy and is very useful for both countries to use such as plant material, based on good scientificknowledge, to obtain new natural preparations for cardiovascular diseases. The full paper presentsin detail, the comparative studies for the plant material described in tables and charts for theresults of all mentioned plant material from both countries.Bibliography:European Pharmacopoeia 7 th ed., Ch. 2.2 - Physical and Physicochemical Methods; Romanian Pharmacopoeia X thed.; Parvu C., Enciclopedia plantelor, vol III, Ed Tehnica, 2004, p. 678.
3. Chemistry in medical and pharmaceutical applications - PNONLINEAR POWER TYPE LAWS – UNIVERSAL CHARACTERISTIC OF DRUGRELEASE FROM POLYMER MATRICESSimona Bacaita, Ancuta Uliniuc, Catalina Peptu, Delia Iurea, Radita Aparaschivei, M. PopaFaculty of Chemical Engineering and Environmental Protection, “Gheorghe Asachi”Technical University of Iasi, Prof. dr. docent Dimitrie Mangeron Rd., No. 73, Iasi, RomaniaThe polymer matrices as drug carriers have the property of controlled release. Theanalyses of the laws that govern the release have shown that these are power type laws ortheir derivatives. This fact indicates the existence of some self-structuring processes in whichthe system finds its own evolution path towards a stable equilibrium state, the differencebeing the system constants. Some examples are presented in Figs.1., where the filled point arethe experimental ones and the joined empty point are the theoretical ones.Levofloxacin release from hydrogels based on starch modifiedwith poli epsilon caprolactone and crosslinked with citric acid1.0Released drug concentration0.80.60.40.2Peppas law : Ckt n0.00 100 200 300 400 500Time min.5 Fluorouracil release from nanocapsules based on poli NVPAIand chitosan , obtained through interfacial condensation0.7Chloramphenicol release from microparticles based on gelatinand poly vinyl alcohol cross linked with glutaraldehideReleased drug concentration1.00.80.60.40.2Weibull law : C 1 e atb0.00 50 100 1500.6Time min .The release of a drug chemically bondedto a macromolecular supportReleased drug concentration0.60.50.40.30.20.1Alfrey law : C k 1 t k 2 t 1 20.00 500 1000 1500Time min.Released drug concentration0.50.40.30.20.1Alfrey law : C k 1 t k 2 t 1 20.00 100 200 300 400Time min.Figs. 1. Release kinetics for different kind of drug loaded polymer matricesAcknowledgement: This paper was supported by the project PERFORM-ERA "PostdoctoralPerformance for Integration in the European Research Area" (ID-57649), financed by theEuropean Social Fund and the Romanian Government.
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INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

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