INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

3. Chemistry in medical and pharmaceutical applications - PTHE STUDY OF PROLONGATION EFFECT OF SOME ANTITUBERCULOUS POLIMERICDRUGS BASED ON N-VINYLPYRROLIDONE AND OTHERIvancic Albert, Duca Gheorghe, Brînză Diana, Robu ŞtefanState University of Moldova, 60, Mateevici str., MD 2009,Chisinau, Republic of MoldovaAnalysis of the scientific data has shown that the number of articles dedicated toobtaining of polimeric antituberculous drugs with prolonged effect has increased lately.Commonly, these medicinal products are less toxic and manifest biological activity for alonger time compared with the micromolecular drugs. Therefore, in order to obtain newpolimeric antituberculous drugs, the copolymers of N-vinylpyrrolidone with methacrylic acidor dextran were coupled with the antituberculous substances such as isoniazid, streptomycin,and other.The synthesis and purification of medicinal polymeric substances were accomplishedwith ethyl chloro formate according to the scheme:COOHCOOH+ H 2N drugClOO C 2H 5OCNHOCNHdrugdrugpolymer support medical polymerChemical structure of conjugated polymers with isoniazid and streptomycin wasconfirmed by IR-spectroscopy, which demonstrated the appearance of new vibrations: ν=3200cm -1 and other, due to formation of peptidic groupOCNHThe study of prolongation effect has been performed using the method of dialysis ofaqueous solutions through a semipermeable cellophane membrane. According to this method,the drug released by polymer in aqueous medium pass through membrane into a aqueousmedium. The transition of drug to the water has been detected using UV-spectra in thewavelength range 200-300nm.It has been found that unlinked isoniazid passes through the semipermiable film for 20-30 min, while the diluted copolymer solutions - up to several hours. Slow detachment of theantituberculous drug from the polymer support can be the cause of the phenomenon ..