INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

3. Chemistry in medical and pharmaceutical applications - ONEW POLYMERIC MATERIALS WITH ANTIMICROBIAL PROPERTIES BASED ONSTYRENE-BUTADIENE COPOLYMERS GRAFTED WITH METHACRYLIC ACID ANDAMPICILLINROBU Stefan 1 , FILIP Vitalie 1 , GHIOCA Paul 2 , SPURCACIU Bogdan 2 , IANCU Lorena 2 ,COSEREA Ramona 2 , PRISACARI Viorel 31 Universitatea de Stat din Moldova, str. A. Mateevici, 60, MD-2012, Chisinău R. Moldova;2Institutul National de Cercetare-Dezvoltare pentru Chimie si Petrochimie ICECHIM, Spl.Independenţei, 202, Sector 6, Bucuresti,3Universitatea de Stat de Medicină “N. Testemiteanu”, Bd. Stefan cel Mare 165, Chisinău, R.Moldova.Many papers published in the last years literature were dedicated to the research ofmedical polymers with prolonged effect and of polymers with antimicrobial, antifungal and otherproperties 10 , 11 . In order to develop new medical polymers, the butadiene-styrene copolymers(SBS) synthesized in ICECHIM Research Institute were grafted with methacrylic acid and thencoupled with antibiotics from ampicillin group as following:The coupling reaction of SBS copolymer (M=89000) with methacrylic acid was achievedat 80 °C in the presence of azobisisobutyronitrile (AIBN) as initiator. Grafted polymerpurification was performed by sedimentation in methanol. The polymer-analogue transformationof SBS-ACM copolymer with ampicillin was realized at 0 °C with ethyl chloroformate. Thepurification was made in diethyl ether. IR spectroscopy and elemental analysis were used toconfirm the structure of the support polymer SBS-ACM (I 0 ) and of the medical one (II 0 ). Thebacteriological tests demonstrated the high antimicrobial effect towards gram-positive and gramnegativemicroorganisms and the fact that the new material can be used for shaping objects withclinical uses.10 Biomedical polymers, Edited by Mike Dj. Jenkins, Boston, Cambridge, 2010;11 N.A. Plată, Polimeri fiziologic activi, Moscova, Știința, 1987 (în limba rusă)