INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

More documents

Recommendations

Info

3. Chemistry in medical and pharmaceutical applications - PHPLC AND UV-VIS COMPARATIVE DETERMINATIONS OF CERTAINANTIOXIDANTS IN SALIX SPECIES, ROSMARINUS OFFICINALIS ANDORIGANUM VULGARE, NATURAL SUBSTITUTES OF ASPIRINPOPESCU Mariana, RIZEA Gabriela Denisa, IONESCU Daniela, IVOPOL Gabriel,IVOPOL MariaS.C.Hofigal Export Import S.A. Str. Intrarea Serelor Nr. 2, Sector 4, BucurestiWell known for their rich content of antioxidants, willow bark (Salix species),rosemary leaves (Rosmarinus officianlis) and origani (Origanum vulgare) can be used asnatural substitutes of aspirine [1-3].HPLC and UV-VIS comparative determinations of poliphenols, flavone andantocianidine derivatives were performed in plant powders and in their extracts. By HPLCmethods were identified various poliphenolcarboxylic acids (chlorogenic, rosemarinic,caffeic, ferulic, p-coumaric), polyphenol - β-glicozide (salicina) besides flavone derivatives(rutin, kaempherol, apigenin, quercitin).UV-VIS spectrophotometric comparative determinations emphasized rich contents ofpoliphenolicarboxilic acids and flavone derivatives in all studied plants. The performeddeterminations were used in the obtaining of natural food supplements aspirine substitutes.___________________1. HARACH T, APRIKIAN O, NONNARY, I., Planta Medica 76 (6), 2010, p. 5662. PINTORE, G., MARCHETTI M., CHESSA M., Natural Product Communication 4 (12), 2009, p. 16853. POSADAS, S.G., CAZ V., LAR GO, C, Experimental Geronitology, 44 (6-7), 2009, p. 383
3. Chemistry in medical and pharmaceutical applications - PSYNTHESIS, STRUCTURE, AND ANTILEUKAEMIA (HL-60) ACTIVITY OFN-(2,4-DIMETHYLPHENYL)HYDRAZINECARBOTHIOAMIDE AND ITS AZOMETHINEDERIVATIVESArtur Sargun 1 , Aurelian Gulea 1 , Alic Barba 2 , Angela Jalba 1 , Donald Poirier 3 ,Pyotr Petrenko 4 , Yuri Chumakov 41 Department of Chemistry and Chemical Engineering, Moldova State University, 60 Mateevici street, Chisinau,Moldova2 Institute of Chemistry, Academy of Sciences of Moldova, 3 Academiei street, Chisinau, Moldova3 Oncology and Molecular Endocrinology Research Centre, CHUL Research Centre and Université Laval, 2705Laurier boulevard, Québec City, Canada4 Institute of Applied Physics, Academy of Sciences of Moldova, 5 Academiei street, Chisinau, MoldovaN-(2,4-dimethylphenyl)hydrazinecarbothioamide 1, as well as its five azomethinederivatives have been obtained by condensation of 1 with: 3-formylpyridine 2, 4-formylpyridine 3, 3-formylthiophene 4, 2-formylquinoline 5, and salicylaldehyde 6. All substances have beentested as inhibitors of human leukaemia (HL-60) cells growth. Antileukaemia bioassays haveScheme 1. The effect on HL-60 cancer cellsDOXO1402Fig. 1. Crystal structure of 1% cell proliferation120100806040203451shown that the antiproliferative0-7 M -6 M -5 MAJ Protocole 504,05,20126activity is manifested mainly within the concentrations 10 μM and 1 μM, and increases in thefollowing series: 2 ≤ 3 < 5 < 1 < 4 < 6 (Scheme 1). Therefore, the most active compounds 4and 6 should be further studied as potential alternatives to traditional antileukaemia drugs.Moreover, from this study we have inferred that in order to synthesise highly antiproliferativeactive azomethines from 1, it should be condensed with aromatic carbocyclic or heterocyclicaldehydes or ketones, which contain donor atoms (such as O or N) in the orto position to thecarbonyl group (e.g. salicylaldehyde, etc.).Bibliography:1. Gulea A., Poirier D., Roy J., Stavila V., Bulimestru I., Tapcov V., Birca M., Popovschi L. In vitroantileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis andstructure - activity relationships // J. Enzym. Inhib. Med. Chem., – 2008. – Vol. 23. – No. 6, – P. 806-818.
Page 1 and 2:
INSTITUTUL NAŢIONAL DE CERCETARE-D
Page 3 and 4:
Toward nontoxic antibiofilm solutio
Page 5 and 6:
FfFevFaFaFeFiFpFa1 Bioresources and
Page 7 and 8:
1 Bioresources and biomaterials - O
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
1 Bioresources and biomaterials - P
Page 15 and 16:
1 Bioresources and biomaterials - P
Page 17 and 18:
1. Bioresurces and biomaterials -PT
Page 19 and 20:
BIOSENSORS BASED ON SCREEN-PRINTED
Page 21 and 22: 1. Bioresurces and biomaterials PSU
Page 23 and 24: 1. 1 Bioresources and biomaterials
Page 25 and 26: 1 Bioresources and biomaterials - P
Page 27 and 28: 1 Bioresources and biomaterials - P
Page 29 and 30: 2. Multifunctional materials and na
Page 31 and 32: REGISTRATION FORM Priochem 8:2. Mul
Page 51 and 52: 3. Chemistry in medical and pharmac
Page 69 and 70: 3 - Chemistry in Medical and Pharma
Page 71: 3. Chemistry in medical and pharmac
Page 75 and 76: 4 - Protection and Environmental En
Page 85 and 86: 4. Protection and environmental eng
Page 87 and 88: 4. Protection and environmental eng
Page 89 and 90: 5. Chemistry and Petrochemistry - O
Page 91 and 92: 5 - Chemistry and Petrochemistry -
Page 93 and 94: Round table: Instalaţie pilot demo
Page 95 and 96: Round table: Trends in Petroleum Re
Page 97 and 98: Round table: Trends in Petrochemist
show all

INSTITUTUL NAÅ¢IONAL DE CERCETARE-DEZVOLTARE - ICECHIM

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?