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Adult Medical Emergency Handbook - Scottish Intensive Care Society

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Causes<br />

• Bradycardia<br />

• Electrolyte disturbances - hypokalaemia/hypomagnesaemia/<br />

hypocalcaemia.<br />

• Tricyclic antidepressants.<br />

• Certain anti-psychotics (e.g. thioridazine).<br />

• IV erythromycin.<br />

• Antihistamines (e.g. terfenadine).<br />

• Anti-arrhythmic drugs - amiodarone, sotalol, disopyramide,<br />

procainamide etc.<br />

• Myocardial ischaemia.<br />

• Inherited long QT syndrome (may be family history of synocope,<br />

sudden death or “epilepsy” in association with any of the above).<br />

Management<br />

• The primary treatment of drug induced Torsade is intravenous<br />

magnesium infusion<br />

• Withdraw any drug known to prolong QT interval<br />

• Consider the use of temporary atrial or ventricular pacing.<br />

• Intravenous isoprenaline (2.25 mg isoprenaline sulphate in 500 mL<br />

5% dextrose infused at 10-30ml per hour) is an effective shortterm<br />

treatment. Use with caution in patients with angina or heart<br />

failure, and discuss management with cardiologist.<br />

VENTRICULAR FIBRILLATION<br />

Characterised by a chaotic electrical pattern with no discernible cardiac<br />

rhythm.<br />

Follow cardiac arrest algorithm.<br />

124 adult medical emergencies handbook | NHS LOTHIAN: UNIVERSITY HOSPITALS DIVISION | 2009/11

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