Clinical Pharmacology and Therapeutics
A Textbook of Clinical Pharmacology and ... - clinicalevidence
A Textbook of Clinical Pharmacology and ... - clinicalevidence
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452 INDEX<br />
aminophylline 238<br />
plasma concentration monitoring 43<br />
4-aminoquinolines 362–3<br />
8-aminoquinolines 364<br />
aminosalicylates 255<br />
amiodarone 221, 224–5<br />
interaction with warfarin 208<br />
monitoring 42–3<br />
amitriptyline, migraine prophylaxis 144<br />
amlodipine 191<br />
ammonia 260<br />
ammonium chloride 279<br />
amoxicillin 326<br />
amphetamines 438–9<br />
on appetite 263<br />
urinary pH <strong>and</strong> 32<br />
amphotericin 341<br />
ciclosporin <strong>and</strong> 402<br />
flucytosine with 344<br />
ganciclovir <strong>and</strong> 347<br />
platinum compounds <strong>and</strong> 374<br />
ampicillin 326<br />
rash 55, 65<br />
amprenavir 356<br />
amyl nitrate 442<br />
amyotrophic lateral sclerosis 129<br />
anabolic steroids 314<br />
abuse 442<br />
for aplastic anaemia 395<br />
ciclosporin <strong>and</strong> 402<br />
anaemia see aplastic anaemia; folate; haemolytic<br />
anaemia; iron; vitamin B 12<br />
anaesthesia 145–54<br />
2 -adrenoceptor agonists 150<br />
benzodiazepines 149<br />
on fetus 46<br />
H 2 -receptor antagonists 250<br />
inhalational 145–8<br />
intravenous 148–9<br />
malignant hyperthermia 80, 83–4, 152<br />
muscle relaxants 150–2<br />
opioids 149–50<br />
pregnancy 48–9<br />
premedication 150<br />
see also local anaesthesia<br />
analgesics 156–64<br />
migraine 142<br />
myocardial infarction 198<br />
nitrous oxide as 147<br />
postoperative 163–4<br />
pregnancy 48<br />
terminal care 162–3<br />
an<strong>and</strong>amide 7<br />
anaphylaxis 404, 405, 406<br />
anastrazole 384<br />
Ancylostoma duodenale, drugs for 365<br />
<strong>and</strong>rogens 313–14<br />
baldness 412<br />
angina 196–8<br />
unstable 196, 198–200<br />
angioplasty, coronary 197–8, 199, 200<br />
angiotensin-converting enzyme inhibitors<br />
187–8<br />
ciclosporin <strong>and</strong> 402<br />
elderly patients 59<br />
heart failure 213<br />
ischaemic heart disease 199, 200, 201<br />
renal failure 37<br />
angiotensin receptor blockers 188–9<br />
elderly patients 59<br />
heart failure 213–14<br />
ischaemic heart disease 199–200, 201<br />
anidulafungin 343<br />
animal studies 4, 87<br />
anion-exchange resins 181, 182<br />
anorectic drugs 262–4<br />
antacids 249, 250<br />
mycophenolate mofetil <strong>and</strong> 403<br />
reflux oesophagitis 252<br />
tetracyclines <strong>and</strong> 329<br />
antagonists 6, 8–9<br />
competitive 8, 9, 10<br />
on effect of partial agonists 9<br />
dose–response curves 6<br />
anterior pituitary hormones 316–18<br />
anthracyclines 377–8<br />
anti-<strong>and</strong>rogens 314, 318<br />
anti-Bcl-2 oligonucleotide 382<br />
anti-CD3 antibody 403<br />
anti-D immunoglobulin 408<br />
anti-dysrhythmic drugs<br />
classification 218, 219<br />
plasma concentration monitoring 42–3<br />
anti-emetics 253–5<br />
with cytotoxic drugs 370<br />
migraine 142<br />
with opioids 163<br />
pregnancy 48–9<br />
anti-epileptic drugs see anticonvulsants<br />
anti-HIV drugs 353–7<br />
interaction with garlic 98<br />
anti-oestrogens, for malignant disease 384<br />
anti-parkinsonian drugs, elderly patients 58<br />
anti-progestogens 311<br />
anti-proliferative immunosuppressants 402–3<br />
anti-sense oligonucleotides 95<br />
antibiotics 323–33<br />
acne 411<br />
antacids <strong>and</strong> 249<br />
chronic obstructive pulmonary disease 236<br />
combinations 72<br />
cytotoxic 377–8<br />
in cytotoxic chemotherapy 371<br />
elderly patients 59<br />
eye infections 427<br />
pregnancy 48<br />
warfarin <strong>and</strong> 208<br />
see also aminoglycosides<br />
anticholinergic drugs 114, 128<br />
chronic obstructive pulmonary disease 236<br />
mydriatics 425<br />
see also muscarinic receptors, antagonists<br />
anticholinesterases 130, 131–2<br />
reversal of muscle relaxants 151<br />
anticoagulants 204, 205–8<br />
combined oral contraceptives <strong>and</strong> 310<br />
DC cardioversion 221<br />
pregnancy 50, 209<br />
sulphonamides <strong>and</strong> 330<br />
thyroid disease 39<br />
anticonvulsants 133–41<br />
interaction with corticosteroids 74<br />
plasma concentration monitoring 42<br />
pregnancy 49<br />
antidepressants 116–23<br />
drug interactions 118<br />
elderly patients 58<br />
see also tricyclic antidepressants<br />
antidiuretic hormone 276–7<br />
antagonists 318<br />
antidotes 72, 446, 447<br />
antifolate analogues 374–5<br />
antihistamines 241, 405–6<br />
eye 427<br />
for vomiting 253–4<br />
antihypertensive drugs 186–95<br />
elderly patients 58<br />
non-steroidal anti-inflammatory drugs <strong>and</strong><br />
168<br />
antilymphocyte globulin 403<br />
antiplatelet drugs 208–9<br />
antipseudomonal penicillins 326<br />
antipsychotic drugs 111–15<br />
antiretroviral agents see anti-HIV drugs<br />
antithrombin III 206<br />
antithyroid drugs 39, 293–5<br />
1 -antitrypsin deficiency 242–3<br />
antitussives 242<br />
antiviral agents 344–9<br />
eye 427<br />
influenza 348<br />
nucleoside analogues 345–7<br />
pregnancy 48<br />
see also anti-HIV drugs<br />
anxiety 107–9<br />
anxiolytics 105, 106, 107–9<br />
aorta, dissecting aneurysms, -adrenoceptor<br />
antagonists 189–90<br />
aplastic anaemia 69, 395<br />
chloramphenicol 328, 395<br />
apnoea, suxamethonium sensitivity 80, 81–2,<br />
152<br />
apolipoprotein A 179<br />
apparent volume of distribution 12<br />
pregnancy 47<br />
appetite stimulation 264<br />
appetite-suppressing drugs 262–4<br />
apraclonidine 426<br />
aqueous humour circulation 425<br />
arachidonic acid 268<br />
cytochrome P450 enzymes on 24–5<br />
metabolism 168<br />
arachis oil 257<br />
aripiprazole 114<br />
aromatase inhibitors 312, 384<br />
arrhythmias see cardiac dysrhythmias<br />
artemether 364<br />
artenusate 364<br />
Arthus reactions 66, 400<br />
arylaminoalcohols 363<br />
ascariasis, drugs for 366<br />
ascites 40<br />
ascorbic acid see vitamin C<br />
aspergillosis, drugs for 340<br />
aspirin 157–8<br />
antacids <strong>and</strong> 249<br />
asthma 157, 243<br />
children <strong>and</strong> 54<br />
ischaemic heart disease 65, 198, 199, 200,<br />
201–2, 208<br />
migraine 142<br />
nicotinic acid <strong>and</strong> 183<br />
poisoning 448<br />
thyroid crisis <strong>and</strong> 295<br />
warfarin <strong>and</strong> 208<br />
asthma 233–5, 236–41<br />
-adrenoceptor antagonists 190<br />
adverse effects of drugs 243<br />
aspirin 157, 243<br />
cough 55<br />
non-steroidal anti-inflammatory drugs <strong>and</strong><br />
168–9, 243<br />
asystole 221<br />
ataxia see cerebellar ataxia<br />
atazanavir 356<br />
atenolol 224<br />
birth weight 45<br />
atheroma 177–84<br />
diabetes mellitus 286<br />
atopic dermatitis 413<br />
atorvastatin 180<br />
atovaquone<br />
malaria prophylaxis 362<br />
Pneumocystis carinii 358<br />
zidovudine <strong>and</strong> 354<br />
ATP binding cassette proteins (ABC proteins)<br />
82<br />
atracurium 150, 151
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