Presentation - University of Colorado Denver

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March 18, 2010 700,000 children and teens (2-19) in Southern California 1/6 <strong>of</strong> children are obese (>95%) 7% boys and 5% girls extremely obese “These kids face 10-20 years shorter life span and will develop health problems in their 20s that we typically see in 40-60 yr olds” Fatty Liver Disease in Obese Youth: 1 in 5.
Trends in child and adolescent overweight Age 6-11 Age 12-19 Age 2-5 Note: Overweight is defined as BMI>=gender and weight-specific 95th percentile from the 2000 CDC Growth Charts. Source: National Health Examination Surveys II (ages 6-11) and III (ages 12-17), National Examination Surveys, I, II, III and 1999-204, NCHS, CDC.
Page 1 and 2: Maternal Nutrition and Metabolic Pr
Page 3 and 4: Colorado Program in Nutrition and H
Page 5 and 6: Outline of Talk: 1) The new science
Page 7: Oct. 6, 2010
Page 12 and 13: World-Wide Childhood Obesity Epidem
Page 14 and 15: Prevalence (%) Prevalence of Type 2
Page 16 and 17: The “Obese Environment” • Adi
Page 18 and 19: When the two combine: Maternal Obes
Page 20 and 21: Co-Morbidities of Childhood Obesity
Page 22 and 23: Global projections for the diabetes
Page 24 and 25: The Developing World is catching up
Page 26 and 27: Fetal Origin of Adult Disease Fetal
Page 28 and 29: Infant Adiposity vs. BW Catalano, A
Page 30 and 31: First take home message: Its not al
Page 32 and 33: Figure 1. Complex Pathogenesis of T
Page 34 and 35: Obese Pregnancy and Fetal Nutrients
Page 36 and 37: NEWS & VIEWS Childhood obesity—me
Page 38 and 39: Adult NAFLD Insulin Resistance Obes
Page 40 and 41: Maternal diet-induced obesity alter
Page 42 and 43: Metabolic Programming in the Fetus:
Page 44 and 45: Benefits and Obstacles to working i
Page 46 and 47: A Primate Model Japanese Macaques @
Page 48 and 49: High Fat Diet Animals High Fat Diet
Page 50 and 51: Fetal Hepatic Pathology Under Condi
Page 52 and 53: -Elevated Stress Response in Fetal
Page 54 and 55: Model showing loss of Sirtuin 3 fun
Page 56 and 57: Chow Maternal Fetal Breast Milk * *
Page 58 and 59: Placenta Histology Control Pregnanc
Page 60 and 61:
Fetal circulating cytokines Include
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Summary: Maternal HFD: • Signific
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Consumption During the Food Prefere
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Offspring from HFD fed mothers exhi
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Maternal HFD increases liver trigly
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(N=2-3 per group) Increased inflamm
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Putative Natural History of Fatty L
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1 Lean Obese GDM Hx Screen: Consent
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Composition •Calories oLactose oP
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Neonatal %Body Fat Correlation Betw
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Roland-Valadez E et al. Ann Hepatol
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Variable ß - coefficient P-value M
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Fetal Hepatic Fat Accumulation Oxid
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Western Diet: High Saturated Fat Hi
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Substrate competition reduces pro-i
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Omega-3 Fatty Acids and Pregnancy:
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Transgenic Animal Model: The Fat-1
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Experiment Outline: 8 week-old Virg
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Fetuses from WT-HFD mothers have si
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What could be causing placental ove
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Lipoprotein Lipase (LPL) activity i
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20 18 16 14 12 10 8 6 4 2 0 Fetal l
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Transcription expression patterns s
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Pups from WT-HFD moms are heavier,
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Could the “liver injury” pathwa
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Summary: Maternal obesity/HFD incre
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Acknowledgments: Mentor: Jed Friedm
Page 118:
Thank You !
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Presentation - University of Colorado Denver

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