Presentation - University of Colorado Denver
Presentation - University of Colorado Denver
Presentation - University of Colorado Denver
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Transgenic Animal Model: The Fat-1 Mouse<br />
- Endogenously converts omega-6s to omega-3s<br />
- Expressed under actin promoter<br />
- Results in a tissue n-6:n-3 ratio ~1:1, without dietary change<br />
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fat-1 (C. elegans):<br />
Encodes n-3 desaturase<br />
J.X. Kang. Prostaglandins, Leukotrienes and Essential Fatty Acids: 77 (2007) 263–267.<br />
Kang et.al. Nature. 2004 Feb 19;427(6976):698.