- Page 1 and 2: Maternal Nutrition and Metabolic Pr
- Page 3 and 4: Colorado Program in Nutrition and H
- Page 5 and 6: Outline of Talk: 1) The new science
- Page 7: Oct. 6, 2010
- Page 12 and 13: World-Wide Childhood Obesity Epidem
- Page 14 and 15: Prevalence (%) Prevalence of Type 2
- Page 16 and 17: The “Obese Environment” • Adi
- Page 18 and 19: When the two combine: Maternal Obes
- Page 20 and 21: Co-Morbidities of Childhood Obesity
- Page 22 and 23: Global projections for the diabetes
- Page 24 and 25: The Developing World is catching up
- Page 26 and 27: Fetal Origin of Adult Disease Fetal
- Page 28 and 29: Infant Adiposity vs. BW Catalano, A
- Page 30 and 31: First take home message: Its not al
- Page 32 and 33: Figure 1. Complex Pathogenesis of T
- Page 34 and 35: Obese Pregnancy and Fetal Nutrients
- Page 36 and 37: NEWS & VIEWS Childhood obesity—me
- Page 38 and 39: Adult NAFLD Insulin Resistance Obes
- Page 40 and 41: Maternal diet-induced obesity alter
- Page 42 and 43: Metabolic Programming in the Fetus:
- Page 44 and 45: Benefits and Obstacles to working i
- Page 46 and 47: A Primate Model Japanese Macaques @
- Page 48 and 49: High Fat Diet Animals High Fat Diet
- Page 50 and 51: Fetal Hepatic Pathology Under Condi
- Page 52 and 53: -Elevated Stress Response in Fetal
- Page 54 and 55: Model showing loss of Sirtuin 3 fun
- Page 56 and 57: Chow Maternal Fetal Breast Milk * *
- Page 58 and 59: Placenta Histology Control Pregnanc
- Page 60 and 61:
Fetal circulating cytokines Include
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Summary: Maternal HFD: • Signific
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Consumption During the Food Prefere
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Offspring from HFD fed mothers exhi
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Maternal HFD increases liver trigly
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(N=2-3 per group) Increased inflamm
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Putative Natural History of Fatty L
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1 Lean Obese GDM Hx Screen: Consent
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Composition •Calories oLactose oP
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Neonatal %Body Fat Correlation Betw
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Roland-Valadez E et al. Ann Hepatol
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Variable ß - coefficient P-value M
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Fetal Hepatic Fat Accumulation Oxid
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Western Diet: High Saturated Fat Hi
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Substrate competition reduces pro-i
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Omega-3 Fatty Acids and Pregnancy:
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Transgenic Animal Model: The Fat-1
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Experiment Outline: 8 week-old Virg
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Fetuses from WT-HFD mothers have si
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What could be causing placental ove
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Lipoprotein Lipase (LPL) activity i
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20 18 16 14 12 10 8 6 4 2 0 Fetal l
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Transcription expression patterns s
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Pups from WT-HFD moms are heavier,
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Could the “liver injury” pathwa
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Summary: Maternal obesity/HFD incre
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Acknowledgments: Mentor: Jed Friedm
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Thank You !